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Literature summary for 2.5.1.47 extracted from

  • Becker, M.A.; Kredich, N.M.; Tomkins, G.M.
    The purification and characterization of O-acetylserine sulfhydrylase-A from Salmonella typhimurium (1969), J. Biol. Chem., 244, 2418-2427.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-cysteine not inhibitory up to 3.7 mM Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5
-
O-acetyl-L-Ser free enzyme Salmonella enterica subsp. enterica serovar Typhimurium
5
-
O-acetyl-L-Ser pH 7.2-7.4, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
5
-
O-acetyl-L-Ser independent of sulfide concentration Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
2 * 34000, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
68000
-
free enzyme, sedimentation equilibrium Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
O-acetyl-L-Ser + sulfide Salmonella enterica subsp. enterica serovar Typhimurium final step in Cys synthesis L-Cys + acetate
-
?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Salmonella enterica subsp. enterica serovar Typhimurium

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1100
-
free enzyme Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Cys + acetate equilibrium constant Salmonella enterica subsp. enterica serovar Typhimurium O-acetyl-L-Ser + H2S
-
r
O-acetyl-L-Ser + H2S equilibrium constant Salmonella enterica subsp. enterica serovar Typhimurium L-Cys + acetate
-
r
O-acetyl-L-Ser + sulfide final step in Cys synthesis Salmonella enterica subsp. enterica serovar Typhimurium L-Cys + acetate
-
?

Subunits

Subunits Comment Organism
dimer 2 * 34000, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
More amino acid analysis, N-terminal amino acid is serine Salmonella enterica subsp. enterica serovar Typhimurium

pH Range

pH Minimum pH Maximum Comment Organism
5.8 9.4
-
Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate 2.1 mol per mol of dimeric enzyme Salmonella enterica subsp. enterica serovar Typhimurium