Any feedback?
Literature summary for 2.5.1.47 extracted from
- Sulphur metabolism in Paracoccus denitrificans. Purification, properties and regulation of serine transacetylase, O-acetylserine sulphydrylase and beta-cystathionase (1977), Biochim. Biophys. Acta, 481, 246-265.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cystathionine | competitive to sulfide | Paracoccus denitrificans |  |
| L-homocysteine | competitive to sulfide | Paracoccus denitrificans | |
| methionine | competitive to sulfide | Paracoccus denitrificans | |
| serine | competitive to O-acetylserine | Paracoccus denitrificans | |
| SO32- | competitive to sulfide | Paracoccus denitrificans | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.25 | - |
H2S | - |
Paracoccus denitrificans | |
| 2.7 | - |
O-acetyl-L-Ser | pH 7.5, 30°C | Paracoccus denitrificans | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Paracoccus denitrificans | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| O-acetyl-L-Ser + sulfide | Paracoccus denitrificans | controlled by feedback inhibition, adaptively significant as sulfide removal mechanism | L-Cys + acetate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Paracoccus denitrificans | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Paracoccus denitrificans |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity increased during growth on cystine, as compared to growth on sulfate | Paracoccus denitrificans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| O-acetyl-L-Ser + sulfide | controlled by feedback inhibition, adaptively significant as sulfide removal mechanism | Paracoccus denitrificans | L-Cys + acetate | - |
? | |
| O-acetyl-L-serine | - |
Paracoccus denitrificans | L-cysteine + acetate | - |
? | |
| O-acetyl-Ser + selenide | maximal 40% rate of cysteine synthesis | Paracoccus denitrificans | selenocysteine + acetate | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 80 | - |
3 min, unstable | Paracoccus denitrificans |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Paracoccus denitrificans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Paracoccus denitrificans | |
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