Organism | UniProt | Comment | Textmining |
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Mus musculus | Q3TXU5 | - |
- |
General Information | Comment | Organism |
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physiological function | in a mouse model that enables the inducible, postnatal deletion of Dhps specifically in postnatal islet beta cells, removal of Dhps does not have an effect under normal physiologic conditions. Upon development of insulin resistance, which induces beta-cell proliferation, Dhps deletion causes alterations in proteins required for mRNA translation and protein secretion, reduced production of the cell cycle molecule cyclin D2, impaired beta-cell proliferation, and induces overt diabetes. Hypusine biosynthesis is downstream of protein kinase C-zeta and is required for c-Myc-induced proliferation | Mus musculus |