Literature summary for 2.5.1.46 extracted from

Aroonsri, A.; Posayapisit, N.; Kongsee, J.; Siripan, O.; Vitsupakorn, D.; Utaida, S.; Uthaipibull, C.; Kamchonwongpaisan, S.; Shaw, P.J.
Validation of Plasmodium falciparum deoxyhypusine synthase as an antimalarial target (2019), PeerJ, 7, e6713 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	of clonal transgenic parasites with integration of glmS riboswitch downstream of the DHS gene	Plasmodium falciparum	5737	-

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	Q8ILW8	-	-

Synonyms

Synonyms	Comment	Organism
DHS	-	Plasmodium falciparum
PF3D7_1412600	-	Plasmodium falciparum

General Information

General Information	Comment	Organism
physiological function	clonal transgenic parasites with integration of glmS riboswitch downstream of the DHS gene show DHS protein in the cytoplasm of in asexual stages. The DHS protein can be attenuated fivefold in transgenic parasites with an active riboswitch. Attenuation of DHS expression for 72 h leads to a significant reduction of hypusinated protein, while global protein synthesis is unaffected. Parasites with attenuated DHS expression show a significant growth defect. DHS-attenuated parasites show increased sensitivity to inhibitor N1-guanyl-1,7-diaminoheptane	Plasmodium falciparum

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Release 2023.1 (January 2023)