Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[eIF5A-precursor]-lysine + spermidine | Homo sapiens | - |
[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P49366 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DU-145 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | (R)-3-methylspermidine competes with spermidine for cellular uptake less efficiently than the (S)-3-methylspermidine | Homo sapiens | ? | - |
? | |
[eIF5A-precursor]-lysine + (R)-3-methylspermidine | no activity with the (S)-enantiomer | Homo sapiens | ? | - |
? | |
[eIF5A-precursor]-lysine + spermidine | - |
Homo sapiens | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
[eIF5A-precursor]-lysine + spermidine | formation of [N(epsilon)-(4-amino-2-hydroxybutyl)lysine] | Homo sapiens | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHS | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | the inability of racemic 3-methylspermidine and (S)-3-methylspermidine to support DU-145 cells growth due to the fact that only the (R)-isomer is a substrate of DHS, but this isomer, (R)-3-methylspermidine, competes with spermidine for cellular uptake and is less efficient than the (S)-3-methylspermidine, which results in accumulation of inactive (S)-3-methylspermidine in the cell. Synthesis of (S)-3-methylspermidine and (R)-3-methylspermidine, overview | Homo sapiens |