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Literature summary for 2.5.1.46 extracted from

  • Woriedh, M.; Hauber, I.; Martinez-Rocha, A.L.; Voigt, C.; Maier, F.J.; Schroeder, M.; Meier, C.; Hauber, J.; Schaefer, W.
    Preventing Fusarium head blight of wheat and cob rot of maize by inhibition of fungal deoxyhypusine synthase (2011), Mol. Plant Microbe Interact., 24, 619-627.
    View publication on PubMed
Search for more literature for 2.5.1.46

Application

Application Comment Organism
drug development fungal DHS is a target for the development of inhibitors, for which CNI-1493 may serve as a lead substance Fusarium graminearum

Cloned(Commentary)

Cloned (Comment) Organism
DHS gene, DNA and amino acid sequence determination and analysis Triticum aestivum
DHS gene, DNA and amino acid sequence determination and analysis Fusarium graminearum

Inhibitors

Inhibitors Comment Organism Structure
CNI-1493 inhibition in vitro and in vivo, inhibits germination conidia. Although DHS of wheat, fungus, and human can be equally inhibited by the inhibitor CNI-1493 in vitro, application during infection of wheat and maize flowers results in strong inhibition of the pathogen without interference with kernel development, providing the possibiity to selectively inhibit fungal growth without affecting plant growth Fusarium graminearum
CNI-1493 inhibition in vitro. Although DHS of wheat, fungus, and human can be equally inhibited by the inhibitor CNI-1493 in vitro, application during infection of wheat and maize flowers results in strong inhibition of the pathogen without interference with kernel development, providing the possibiity to selectively inhibit fungal growth without affecting plant growth Triticum aestivum
CNI-1493 inhibition in vitro. Although DHS of wheat, fungus, and human can be equally inhibited by the inhibitor CNI-1493 in vitro, application during infection of wheat and maize flowers results in strong inhibition of the pathogen without interference with kernel development, providing the possibiity to selectively inhibit fungal growth without affecting plant growth Zea mays

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41400
-
 x * 41400, about, sequence calculation Triticum aestivum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[eIF5A-precursor]-lysine + spermidine Triticum aestivum
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
[eIF5A-precursor]-lysine + spermidine Zea mays
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
[eIF5A-precursor]-lysine + spermidine Fusarium graminearum
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
[eIF5A-precursor]-lysine + spermidine Fusarium graminearum FG00323.1
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Organism

Organism UniProt Comment Textmining
Fusarium graminearum
-
-
-
Fusarium graminearum FG00323.1
-
-
-
Triticum aestivum
-
-
-
Zea mays
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Triticum aestivum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[eIF5A-precursor]-lysine + spermidine
-
 Triticum aestivum [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
[eIF5A-precursor]-lysine + spermidine
-
 Zea mays [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
[eIF5A-precursor]-lysine + spermidine
-
 Fusarium graminearum [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
[eIF5A-precursor]-lysine + spermidine
-
 Fusarium graminearum FG00323.1 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Subunits

Subunits Comment Organism
? x * 41400, about, sequence calculation Triticum aestivum