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Literature summary for 2.5.1.46 extracted from

  • Hyvoenen, M.T.; Keinaenen, T.A.; Khomutov, M.; Simonian, A.; Vepsaelaeinen, J.; Park, J.H.; Khomutov, A.R.; Alhonen, L.; Park, M.H.
    Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A (2012), Amino Acids, 42, 685-695.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.46

Inhibitors

Inhibitors Comment Organism Structure
2-methylspermidine
-
 Homo sapiens
3-methylspermidine
-
 Homo sapiens
4-methylspermidine
-
 Homo sapiens
N-(3-aminopropyl)-N'-methylbutane-1,4-diamine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens as racemic mixtures, only 2-MeSpd and 3-MeSpd support long-term growth (9-18 days) of spermidine-depleted DU-145 cells, whereas gamma-MeSpd and omega-MeSpd do not ?
-
 ?
[eIF5A-precursor]-lysine + 2-methylspermidine Homo sapiens
-
 ?
-
 ?
[eIF5A-precursor]-lysine + 3-methylspermidine Homo sapiens
-
 ?
-
 ?
[eIF5A-precursor]-lysine + spermidine Homo sapiens
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information as racemic mixtures, only 2-MeSpd and 3-MeSpd support long-term growth (9-18 days) of spermidine-depleted DU-145 cells, whereas gamma-MeSpd and omega-MeSpd do not Homo sapiens ?
-
 ?
[eIF5A-precursor]-lysine + 2-methylspermidine
-
 Homo sapiens ?
-
 ?
[eIF5A-precursor]-lysine + 2-methylspermidine the S-enantiomer of 2-MeSpd, which supports long-term growth, is a good substrate for DHS in vitro, whereas the R isomer is not Homo sapiens ?
-
 ?
[eIF5A-precursor]-lysine + 3-methylspermidine
-
 Homo sapiens ?
-
 ?
[eIF5A-precursor]-lysine + 4-methylspermidine
-
 Homo sapiens ?
-
 ?
[eIF5A-precursor]-lysine + spermidine
-
 Homo sapiens [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ir

Synonyms

Synonyms Comment Organism
DHS
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function hypusine modification is an irreversible protein modification and naturally occurring eIF5A exists predominantly as the hypusinated form. Deoxyhypusine synthase catalyzes the transfer of the aminobutyl moiety from spermidine to a specific lysine of the eIF5A precursor to form the deoxyhypusine [N?-(4-aminobutyl)lysine] intermediate. Hypusine is formed from deoxyhypusine by the action of EC 1.14.99.29, deoxyhypusine monooxygenase Homo sapiens