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Literature summary for 2.5.1.46 extracted from

  • Park, M.H.; Nishimura, K.; Zanelli, C.F.; Valentini, S.R.
    Functional significance of eIF5A and its hypusine modification in eukaryotes (2010), Amino Acids, 38, 491-500.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
-
single gene
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Saccharomyces cerevisiae
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single gene
-

Synonyms

Synonyms Comment Organism
deoxyhypusine synthase
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Mus musculus
deoxyhypusine synthase
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Saccharomyces cerevisiae
DHS
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Mus musculus
DHS
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Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction a haploid Saccharomyces cerevisiae strain with disruption of the DHS gene is not viable, and can be rescued by a plasmid encoding the wild type DHS. When examined under the microscope, a non-viable DHS-disrupted ascus from a tetrad dissection grows several generations to a colony of 100-200 enlarged cells before growth arrest Saccharomyces cerevisiae
malfunction Dhps+/- mice appear normal and do not show any growth defects or phenotypes. When the heterozygous male and female mice are crossed, no pups are born with the genotype of Dhps-/- homozygous deletion, indicating that DHS is vital for growth and survival Mus musculus