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Literature summary for 2.5.1.46 extracted from

  • Park, J.H.; Wolff, E.C.; Folk, E.C.; Park, M.H.
    Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase (2003), J. Biol. Chem., 278, 32683-32691.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,7-Diaminoheptane inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine Homo sapiens
6,6'-difluorospermidine inhibition of deoxyhypusine synthesis Homo sapiens
aminopropylcadaverine inhibition of deoxyhypusine synthesis Homo sapiens
caldine inhibition of deoxyhypusine synthesis Homo sapiens
Homospermidine inhibition of deoxyhypusine synthesis Homo sapiens
N-(3-aminopropyl)-1,4-diamino-cis-but-2-ene
-
Homo sapiens
N-(3-aminopropyl)-1,4-diamino-trans-but-2-ene
-
Homo sapiens
N1-ethylspermidine inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine Homo sapiens
N1-guanyl-1,7-diaminoheptane inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine Homo sapiens
N1-methylspermidine inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine Homo sapiens
spermidine inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0015
-
putrescine
-
Homo sapiens
0.0066
-
[eIF5A-precursor]-deoxyhypusine pH 7.5 Homo sapiens
0.00726
-
spermidine reaction with eIF5A-precursor Homo sapiens
0.0086
-
[eIF5A-precursor]-deoxyhypusine pH 9.5 Homo sapiens
0.0193
-
homospermine
-
Homo sapiens
0.028
-
spermidine reaction with putrescine Homo sapiens
0.0954
-
1,3-diaminopropane pH 7.5 Homo sapiens
0.1058
-
1,3-diaminopropane pH 9.5 Homo sapiens
0.203
-
putrescine
-
Homo sapiens
1.12
-
[eIF5A-precursor]-L-lysine
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-ethylspermidine + putrescine
-
Homo sapiens homospermidine + ?
-
?
1-ethylspermidine + [eIF5A-precursor]-lysine
-
Homo sapiens [eIF5A-precursor]-deoxyhypusine + ?
-
?
1-methylspermidine + putrescine
-
Homo sapiens homospermidine + ?
-
?
1-methylspermidine + [eIF5A-precursor]-lysine
-
Homo sapiens [eIF5A-precursor]-deoxyhypusine + ?
-
?
8-ethylspermidine + putrescine
-
Homo sapiens ethylhomospermidine + ?
-
?
8-ethylspermidine + [eIF5A-precursor]-lysine
-
Homo sapiens [eIF5A-precursor]-ethyldeoxyhypusine + ?
-
?
8-methylspermidine + putrescine
-
Homo sapiens methylhomospermidine + ?
-
?
8-methylspermidine + [eIF5A-precursor]-lysine
-
Homo sapiens [eIF5A-precursor]-methyldeoxyhypusine + ?
-
?
aminopropylcadaverine + [eIF5A-precursor]-lysine
-
Homo sapiens [eIF5A-precursor]-homodeoxyhypusine + ?
-
?
caldine + putrescine
-
Homo sapiens spermidine + ?
-
?
homospermidine + putrescine
-
Homo sapiens homospermidine + ?
-
?
homospermidine + [eIF5A-precursor]-lysine
-
Homo sapiens [eIF5A-precursor]-deoxyhypusine + ?
-
?
homospermine + [eIF5A-precursor]-lysine
-
Homo sapiens ?
-
?
N-(3-aminopropyl)-1,4-diamino-cis-but-2-ene + putrescine
-
Homo sapiens (1Z)-N4-(4-aminobutyl)but-1-ene-1,4-diamine + 1,3-diaminopropane
-
?
N-(3-aminopropyl)-1,4-diamino-cis-but-2-ene + [eIF5A-precursor]-lysine
-
Homo sapiens ?
-
?
N-(3-aminopropyl)-1,4-diamino-trans-but-2-ene + putrescine
-
Homo sapiens (1E)-N4-(4-aminobutyl)but-1-ene-1,4-diamine + 1,3-diaminopropane
-
?
N-(3-aminopropyl)-1,4-diamino-trans-but-2-ene + [eIF5A-precursor]-lysine
-
Homo sapiens ?
-
?
spermidine + putrescine
-
Homo sapiens homospermidine + ?
-
?
[eIF5A-precursor]-lysine + spermidine reversal of reaction in presence of NAD+ Homo sapiens [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens