Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,7-Diaminoheptane | inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine | Homo sapiens | |
6,6'-difluorospermidine | inhibition of deoxyhypusine synthesis | Homo sapiens | |
aminopropylcadaverine | inhibition of deoxyhypusine synthesis | Homo sapiens | |
caldine | inhibition of deoxyhypusine synthesis | Homo sapiens | |
Homospermidine | inhibition of deoxyhypusine synthesis | Homo sapiens | |
N-(3-aminopropyl)-1,4-diamino-cis-but-2-ene | - |
Homo sapiens | |
N-(3-aminopropyl)-1,4-diamino-trans-but-2-ene | - |
Homo sapiens | |
N1-ethylspermidine | inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine | Homo sapiens | |
N1-guanyl-1,7-diaminoheptane | inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine | Homo sapiens | |
N1-methylspermidine | inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine | Homo sapiens | |
spermidine | inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0015 | - |
putrescine | - |
Homo sapiens | |
0.0066 | - |
[eIF5A-precursor]-deoxyhypusine | pH 7.5 | Homo sapiens | |
0.00726 | - |
spermidine | reaction with eIF5A-precursor | Homo sapiens | |
0.0086 | - |
[eIF5A-precursor]-deoxyhypusine | pH 9.5 | Homo sapiens | |
0.0193 | - |
homospermine | - |
Homo sapiens | |
0.028 | - |
spermidine | reaction with putrescine | Homo sapiens | |
0.0954 | - |
1,3-diaminopropane | pH 7.5 | Homo sapiens | |
0.1058 | - |
1,3-diaminopropane | pH 9.5 | Homo sapiens | |
0.203 | - |
putrescine | - |
Homo sapiens | |
1.12 | - |
[eIF5A-precursor]-L-lysine | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-ethylspermidine + putrescine | - |
Homo sapiens | homospermidine + ? | - |
? | |
1-ethylspermidine + [eIF5A-precursor]-lysine | - |
Homo sapiens | [eIF5A-precursor]-deoxyhypusine + ? | - |
? | |
1-methylspermidine + putrescine | - |
Homo sapiens | homospermidine + ? | - |
? | |
1-methylspermidine + [eIF5A-precursor]-lysine | - |
Homo sapiens | [eIF5A-precursor]-deoxyhypusine + ? | - |
? | |
8-ethylspermidine + putrescine | - |
Homo sapiens | ethylhomospermidine + ? | - |
? | |
8-ethylspermidine + [eIF5A-precursor]-lysine | - |
Homo sapiens | [eIF5A-precursor]-ethyldeoxyhypusine + ? | - |
? | |
8-methylspermidine + putrescine | - |
Homo sapiens | methylhomospermidine + ? | - |
? | |
8-methylspermidine + [eIF5A-precursor]-lysine | - |
Homo sapiens | [eIF5A-precursor]-methyldeoxyhypusine + ? | - |
? | |
aminopropylcadaverine + [eIF5A-precursor]-lysine | - |
Homo sapiens | [eIF5A-precursor]-homodeoxyhypusine + ? | - |
? | |
caldine + putrescine | - |
Homo sapiens | spermidine + ? | - |
? | |
homospermidine + putrescine | - |
Homo sapiens | homospermidine + ? | - |
? | |
homospermidine + [eIF5A-precursor]-lysine | - |
Homo sapiens | [eIF5A-precursor]-deoxyhypusine + ? | - |
? | |
homospermine + [eIF5A-precursor]-lysine | - |
Homo sapiens | ? | - |
? | |
N-(3-aminopropyl)-1,4-diamino-cis-but-2-ene + putrescine | - |
Homo sapiens | (1Z)-N4-(4-aminobutyl)but-1-ene-1,4-diamine + 1,3-diaminopropane | - |
? | |
N-(3-aminopropyl)-1,4-diamino-cis-but-2-ene + [eIF5A-precursor]-lysine | - |
Homo sapiens | ? | - |
? | |
N-(3-aminopropyl)-1,4-diamino-trans-but-2-ene + putrescine | - |
Homo sapiens | (1E)-N4-(4-aminobutyl)but-1-ene-1,4-diamine + 1,3-diaminopropane | - |
? | |
N-(3-aminopropyl)-1,4-diamino-trans-but-2-ene + [eIF5A-precursor]-lysine | - |
Homo sapiens | ? | - |
? | |
spermidine + putrescine | - |
Homo sapiens | homospermidine + ? | - |
? | |
[eIF5A-precursor]-lysine + spermidine | reversal of reaction in presence of NAD+ | Homo sapiens | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine | r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |