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Literature summary for 2.5.1.46 extracted from
- Molecular cloning and functional expression of Neurospora deoxyhypusine synthase cDNA and identification of yeast deoxyhypusine synthase cDNA (1995), J. Biol. Chem., 270, 23984-23987.
General Stability
| General Stability | Organism |
|---|---|
| freeze-thawing of the partially purified enzyme inactivates, no stabilization by glycerol | Neurospora crassa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| iodoacetate | - |
Neurospora crassa |  |
| NEM | - |
Neurospora crassa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Saccharomyces cerevisiae | 5737 | - |
| cytoplasm | - |
Neurospora crassa | 5737 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
4 * 40000, SDS-PAGE | Neurospora crassa |
| 180000 | - |
gel filtration | Neurospora crassa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [eIF5A-precursor]-lysine + spermidine | Saccharomyces cerevisiae | - |
[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
| [eIF5A-precursor]-lysine + spermidine | Neurospora crassa | - |
[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Neurospora crassa | P49365 | - |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [eIF5A-precursor]-lysine + spermidine | - |
Saccharomyces cerevisiae | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
| [eIF5A-precursor]-lysine + spermidine | - |
Neurospora crassa | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
| [eIF5A-precursor]-lysine + spermidine | - |
Saccharomyces cerevisiae | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine | ? | |
| [eIF5A-precursor]-lysine + spermidine | - |
Neurospora crassa | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | - |
Saccharomyces cerevisiae |
| tetramer | 4 * 40000, SDS-PAGE | Neurospora crassa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Saccharomyces cerevisiae | |
| NAD+ | - |
Neurospora crassa | |
| NADH | - |
Saccharomyces cerevisiae | |
| NADH | - |
Neurospora crassa | |
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