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Literature summary for 2.5.1.46 extracted from

  • Ober, D.; Hartmann, T.
    Deoxyhypusine synthase from tobacco. cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity (1999), J. Biol. Chem., 274, 32040-32047.
    View publication on PubMed
Search for more literature for 2.5.1.46

Cloned(Commentary)

Cloned (Comment) Organism
-
 Nicotiana tabacum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42074
-
 4 * 42074, calculation from amino acid sequence Nicotiana tabacum
190000
-
 gel filtration Nicotiana tabacum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[eIF5A-precursor]-lysine + spermidine Nicotiana tabacum
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Organism

Organism UniProt Comment Textmining
Nicotiana tabacum Q9SC80
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0034
-
 with donor homospermidine Nicotiana tabacum
0.0091
-
 with donor homospermidine Nicotiana tabacum
0.0211
-
 with donor spermidine Nicotiana tabacum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
spermidine + putrescine
-
 Nicotiana tabacum homospermidine + ?
-
 ?
[eIF5A-precursor]-lysine + homospermidine
-
 Nicotiana tabacum [eIF5A-precursor]-deoxyhypusine + putrescine
-
 ?
[eIF5A-precursor]-lysine + spermidine
-
 Nicotiana tabacum [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
[eIF5A-precursor]-lysine + spermidine
-
 Nicotiana tabacum [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine ?

Subunits

Subunits Comment Organism
tetramer 4 * 42074, calculation from amino acid sequence Nicotiana tabacum

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Nicotiana tabacum
NADH
-
 Nicotiana tabacum