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Literature summary for 2.5.1.43 extracted from

  • Nozoye, T.; Tsunoda, K.; Nagasaka, S.; Bashir, K.; Takahashi, M.; Kobayashi, T.; Nakanishi, H.; Nishizawa, N.K.
    Rice nicotianamine synthase localizes to particular vesicles for proper function (2014), Plant Signal. Behav., 9, e28660.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.43

Cloned(Commentary)

Cloned (Comment) Organism
gene ZmNAS1;1, located on chromosome 9, genotying and phylogenetic analysis, sequence comparisons, expression analysis Zea mays
gene ZmNAS1;2, located on chromosome 9, genotying and phylogenetic analysis, sequence comparisons, expression analysis Zea mays
gene ZmNAS2;1, located on chromosome 1, genotying and phylogenetic analysis, sequence comparisons, expression analysis Zea mays
gene ZmNAS2;2, located on chromosome 1, genotying and phylogenetic analysis, sequence comparisons, expression analysis Zea mays
gene ZmNAS3, located on chromosome 1, genotying and phylogenetic analysis, sequence comparisons, expression analysis Zea mays
gene ZmNAS4, located on chromosome 5, genotying and phylogenetic analysis, sequence comparisons, expression analysis Zea mays
gene ZmNAS5, located on chromosome 7, genotying and phylogenetic analysis, sequence comparisons, expression analysis Zea mays
gene ZmNAS6;1, located on chromosome 9, genotying and phylogenetic analysis, sequence comparisons, expression analysis Zea mays
gene ZmNAS6;2, located on chromosome 9, genotying and phylogenetic analysis, sequence comparisons, expression analysis Zea mays
recombinant expression of GFP-tagged isozyme OsNAS2 in Oryza sativa roots. OsNAS2-sGFP vesicles move dynamically in the cells. Fe homeostasis is disturbed in the GFP-tagged OsNAS2 plants, and these plants receive Fe-deficiency signals even under Fe-sufficient conditions, this is probably due to to the overproduction of deocxymugineic acid and nicotinamine, which increases the chelating capacity of Fe and disrupts an unknown Fe-sensing mechanism Oryza sativa

Protein Variants

Protein Variants Comment Organism
additional information isozyme OsNAS2 mutated in the YXXphi motif, mutant m6-sGFP, is localized to the vesicles. These vesicles stuck together and are immobile. OsNAS2 mutated in the LL motif, mutant m7-sGFP, does not localize to these vesicles Oryza sativa

Localization

Localization Comment Organism GeneOntology No. Textmining
vesicle model for OsNAS2-localized vesicles in Oryza sativa Oryza sativa 31982
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine Zea mays
-
 3 S-methyl-5'-thioadenosine + nicotianamine
-
 ?

Organism

Organism UniProt Comment Textmining
Oryza sativa Q10MI9 subsp. indica, gene NAS2
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Zea mays A0A1D6GLB9 gene ZmNAS4
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Zea mays A0A1D6IP14 gene ZmNAS5
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Zea mays A0A1D6K0A7 gene ZmNAS2;2
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Zea mays A0A1D6K0A8 gene ZmNAS2;1 or ZmNAS2
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Zea mays B4FAC0 gene ZmNAS6;1
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Zea mays K7VIY6 gene ZmNAS6;2
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Zea mays K7WE51 gene ZmNAS1;2
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Zea mays Q8LT22 gene ZmNAS3
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Zea mays Q8S9C5 gene ZmNAS1;1 or ZmNAS1
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Posttranslational Modification

Posttranslational Modification Comment Organism
additional information modeling of posttranscriptional mRNA degradation and/or posttranslational protein degradation of isozyme OsNAS2 Oryza sativa

Source Tissue

Source Tissue Comment Organism Textmining
axillary meristem
-
 Zea mays
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epidermis of roots Zea mays
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leaf primordia, low expression level Zea mays
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leaf ZmNAS3 is predominantly accumulated in leaves, expression in young leaves, mainly in the leaf primordia and mesophyll cells in young leaves Zea mays
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mesophyll cell
-
 Zea mays
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additional information isozyme issue expression patterns, overview. No ZmNAS1;1 expression in shoots Zea mays
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additional information isozyme tissue expression patterns, overview Zea mays
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additional information isozyme tissue expression patterns, overview. No ZmNAS1;2 expression in shoots Zea mays
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root
-
 Oryza sativa
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root cortex and stele, epidermis Zea mays
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seed developing Zea mays
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shoot low expression level, mainly in axillary meristems in shoot apices Zea mays
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine
-
 Zea mays 3 S-methyl-5'-thioadenosine + nicotianamine
-
 ?

Synonyms

Synonyms Comment Organism
NA synthase 2
-
 Oryza sativa
OsNA S2
-
 Oryza sativa
ZmNAS1;1
-
 Zea mays
ZmNAS1;2
-
 Zea mays
ZmNAS2;1
-
 Zea mays
ZmNAS2;2
-
 Zea mays
ZmNAS3
-
 Zea mays
ZmNAS4
-
 Zea mays
ZmNAS5
-
 Zea mays
ZmNAS6;1
-
 Zea mays
ZmNAS6;2
-
 Zea mays

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Zea mays

Expression

Organism Comment Expression
Zea mays class I ZmNAS genes are induced under Fe deficiency and are suppressed under Fe excessive conditions, while the expression pattern of class II genes are opposite to class I. Expression patterns of ZmNAS genes in response to fluctuating metal status down
Zea mays class I ZmNAS genes are induced under Fe deficiency and are suppressed under Fe excessive conditions, while the expression pattern of class II genes are opposite to class I. Expression patterns of ZmNAS genes in response to fluctuating metal status. Class I genes are suppressed in response to Zn excess and Cu/Mn deficiency down
Zea mays class I ZmNAS genes are induced under Fe deficiency and are suppressed under Fe excessive conditions, while the expression pattern of class II genes are opposite to class I. Expression patterns of ZmNAS genes in response to fluctuating metal status. Class I ZmNAS genes are stimulated under Zn deficiency up
Zea mays class I ZmNAS genes are induced under Fe deficiency and are suppressed under Fe excessive conditions, while the expression pattern of class II genes are opposite to class I. Expression patterns of ZmNAS genes in response to fluctuating metal status. Class II genes are induced under excessive Zn and deficient Cu/Mn conditions up

General Information

General Information Comment Organism
evolution complementary expression patterns of class I and class II ZmNAS genes in response to Fe confirms the classification of this family, ZmNAS1;1 is a class I enzyme Zea mays
evolution complementary expression patterns of class I and class II ZmNAS genes in response to Fe confirms the classification of this family, ZmNAS1;2 is a class I enzyme Zea mays
evolution complementary expression patterns of class I and class II ZmNAS genes in response to Fe confirms the classification of this family, ZmNAS2;1 is a class I enzyme Zea mays
evolution complementary expression patterns of class I and class II ZmNAS genes in response to Fe confirms the classification of this family, ZmNAS2;2 is a class I enzyme Zea mays
evolution complementary expression patterns of class I and class II ZmNAS genes in response to Fe confirms the classification of this family, ZmNAS3 is a class II enzyme Zea mays
evolution complementary expression patterns of class I and class II ZmNAS genes in response to Fe confirms the classification of this family, ZmNAS4 is a class II enzyme Zea mays
evolution complementary expression patterns of class I and class II ZmNAS genes in response to Fe confirms the classification of this family, ZmNAS5 is a class II enzyme Zea mays
evolution complementary expression patterns of class I and class II ZmNAS genes in response to Fe confirms the classification of this family, ZmNAS6;1 is a class I enzyme Zea mays
evolution complementary expression patterns of class I and class II ZmNAS genes in response to Fe confirms the classification of this family, ZmNAS6;2 is a class I enzyme Zea mays
malfunction mutation of the N-terminal tyrosine motif or di-leucine motif of isozyme OsNAS2, involved in cellular transport, causes a disruption in vesicular movement and vesicular localization, respectively. Fe homeostasis is disturbed in the GFP-tagged OsNAS2 plants, and these plants receive Fe-deficiency signals even under Fe-sufficient conditions, this is probably due to to the overproduction of deocxymugineic acid and nicotinamine, which increases the chelating capacity of Fe and disrupts an unknown Fe-sensing mechanism. OsNAS2-sGFP plants grow more slowly than the wild-type and the mutant m6-sGFP and m7-sGFP plants Oryza sativa
additional information the enzyme's tyrosine motif is involved in vesicle movement, whereas the di-leucine motif is involved in vesicle localization and OsNAS2 activity, which are crucial for the proper function of OsNAS2 Oryza sativa
physiological function class I ZmNAS genes may be involved in the Fe uptake in roots and long distance translocation in stems Zea mays
physiological function class II ZmNAS genes may contribute to the local transportation of Fe Zea mays
physiological function class II ZmNAS genes may contribute to the local transportation of Fe. ZmNAS3, a member of class II ZmNAS genes, may participate in the local transportation and homeostasis of Fe in developing tissues Zea mays
physiological function graminaceous plants utilize a chelation strategy to acquire Fe from soil that involves the secretion of mugineic acid family phytosiderophores (MAs), which chelate and solubilize Fe(III) in the rhizosphere from their roots through transporter of mugineic acids 1 (TOM1). The resultant Fe(III)-MAs complexes are absorbed by root cells through a transporter protein YSL. Rice produces and secretes 2'-deoxymugineic acid (DMA). DMA is synthesized from S-adenosylmethionine through a nicotianamine (NA) intermediate8 by 3 enzymes: NA synthase (NAS), NA aminotransferase (NAAT), and DMA synthase. Nicotinamine is a structural analog of mugineic acid, and is responsible for metal homeostasis through metal translocation in plants. Particular vesicles, originating from the rough endoplasmic reticulum, are involved in deoxymugineic acid and nicotianamine biosynthesis and in deoxymugineic acid secretion from Oryza sativa roots. Modeling of the intracellular transport of mugineic acid-vesicles in rice roots Oryza sativa