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Literature summary for 2.5.1.39 extracted from

  • Liu, Y.; Ding, X.; Xue, Z.; Hu, L.; Cheng, Q.; Chen, M.; Su, Y.; Zhu, B.; Xu, P.
    Site-directed mutagenesis of UbiA to promote menaquinone biosynthesis in Elizabethkingia meningoseptica (2017), Proc. Biochem., 58, 186-192 .
No PubMed abstract available
Search for more literature for 2.5.1.39

Protein Variants

Protein Variants Comment Organism
D198A mutation enhances the expression of 1,4-dihydroxy-2-naphthoic acid octaprenyltransferase (MenA), which increases menaquinone production by 130.0% Elizabethkingia meningoseptica
D76A mutation enhances the expression of 1,4-dihydroxy-2-naphthoic acid octaprenyltransferase (MenA), which increases menaquinone production by 87.9% Elizabethkingia meningoseptica
G68A mutation has no influence on expression of 1,4-dihydroxy-2-naphthoic acid octaprenyltransferase (MenA) Elizabethkingia meningoseptica
K81A mutation enhances the expression of 1,4-dihydroxy-2-naphthoic acid octaprenyltransferase (MenA), which increases menaquinone production by 96.2% Elizabethkingia meningoseptica
L139A mutation enhances the expression of 1,4-dihydroxy-2-naphthoic acid octaprenyltransferase (MenA), which increases menaquinone production by 109.7% Elizabethkingia meningoseptica
N72A mutation enhances the expression of 1,4-dihydroxy-2-naphthoic acid octaprenyltransferase (MenA), which increases menaquinone production by 127.1% Elizabethkingia meningoseptica
S61A mutation has no influence on expression of 1,4-dihydroxy-2-naphthoic acid octaprenyltransferase (MenA) Elizabethkingia meningoseptica

Organism

Organism UniProt Comment Textmining
Elizabethkingia meningoseptica WP_026149280
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Synonyms

Synonyms Comment Organism
4-hydroxybenzoate octaprenyl transferase
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 Elizabethkingia meningoseptica
ubiA
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 Elizabethkingia meningoseptica

General Information

General Information Comment Organism
metabolism the enzyme is involved in menaquinone biosynthesis. Blocking ubiquinone synthesis pathway by site-directed mutagenesis of the active site of UbiA in Elizabethkingia meningoseptica is a promising strategy to increase menaquinone K production in Elizabethkingia meningoseptica Elizabethkingia meningoseptica