BRENDA - Enzyme Database
show all sequences of 2.5.1.39

Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ

Forsgren, M.; Attersand, A.; Lake, S.; Gruenler, J.; Swiezewska, E.; Dallner, G.; Climent, I.; Biochem. J. 382, 519-526 (2004)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
gene COQ2, complementation of yeast Coq2 null mutant cells
Saccharomyces cerevisiae
gene COQ2, DNA and amino acid sequence determination and analysis, functional expression in and complementation of yeast Coq2 null mutant cells, CoQ biosynthesis rate is lower in the yeast cells when rescued with the human enzyme compared to cells rescued with the yeast enzyme
Homo sapiens
Engineering
Protein Variants
Commentary
Organism
additional information
CoQ biosynthesis in yeast null mutant cells can be rescued with expression of the human enzyme at a lower rate compared to cells rescued with the yeast enzyme
Saccharomyces cerevisiae
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
the enzyme contains 6 transmembrane sequences
Homo sapiens
16020
-
mitochondrion
-
Homo sapiens
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
decaprenyl diphosphate + 4-hydroxybenzoate
Saccharomyces cerevisiae
-
diphosphate + decaprenyl-4-hydroxybenzoate
-
-
?
decaprenyl diphosphate + 4-hydroxybenzoate
Homo sapiens
-
diphosphate + decaprenyl-4-hydroxybenzoate
-
-
?
additional information
Saccharomyces cerevisiae
the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone
?
-
-
?
additional information
Homo sapiens
the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone
?
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
Saccharomyces cerevisiae
-
diphosphate + nonaprenyl-4-hydroxybenzoate
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
Homo sapiens
-
diphosphate + nonaprenyl-4-hydroxybenzoate
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
Q96H96
-
-
Saccharomyces cerevisiae
-
gene COQ2
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adrenal gland
high enzyme expression
Homo sapiens
-
brain
fetal
Homo sapiens
-
heart
high enzyme expression
Homo sapiens
-
liver
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
skeletal muscle
high enzyme expression
Homo sapiens
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
activity in recombinant yeast cells
Saccharomyces cerevisiae
additional information
-
activity in recombinant yeast cells
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
decaprenyl diphosphate + 4-hydroxybenzoate
-
657846
Saccharomyces cerevisiae
diphosphate + decaprenyl-4-hydroxybenzoate
-
-
-
?
decaprenyl diphosphate + 4-hydroxybenzoate
-
657846
Homo sapiens
diphosphate + decaprenyl-4-hydroxybenzoate
-
-
-
?
decaprenyl diphosphate + 4-hydroxybenzoate
preferred substrate
657846
Homo sapiens
diphosphate + decaprenyl-4-hydroxybenzoate
-
-
-
?
additional information
the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone
657846
Saccharomyces cerevisiae
?
-
-
-
?
additional information
the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone
657846
Homo sapiens
?
-
-
-
?
additional information
the enzyme catalyzes the prenylation of 4-hydroxybenzoate with an all-trans polyprenyl group
657846
Saccharomyces cerevisiae
?
-
-
-
?
additional information
the enzyme catalyzes the prenylation of 4-hydroxybenzoate with an all-trans polyprenyl group
657846
Homo sapiens
?
-
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
-
657846
Saccharomyces cerevisiae
diphosphate + nonaprenyl-4-hydroxybenzoate
-
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
-
657846
Homo sapiens
diphosphate + nonaprenyl-4-hydroxybenzoate
-
-
-
?
Subunits
Subunits
Commentary
Organism
More
the enzyme contains 6 transmembrane sequences and an UbiA domain
Homo sapiens
Synonyms
Synonyms
Commentary
Organism
COQ2
-
Homo sapiens
p-hydroxybenzoate:polyprenyl transferase
-
Homo sapiens
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Saccharomyces cerevisiae
30
-
assay at
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Saccharomyces cerevisiae
7.4
-
assay at
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
gene COQ2, complementation of yeast Coq2 null mutant cells
Saccharomyces cerevisiae
gene COQ2, DNA and amino acid sequence determination and analysis, functional expression in and complementation of yeast Coq2 null mutant cells, CoQ biosynthesis rate is lower in the yeast cells when rescued with the human enzyme compared to cells rescued with the yeast enzyme
Homo sapiens
Engineering (protein specific)
Protein Variants
Commentary
Organism
additional information
CoQ biosynthesis in yeast null mutant cells can be rescued with expression of the human enzyme at a lower rate compared to cells rescued with the yeast enzyme
Saccharomyces cerevisiae
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
the enzyme contains 6 transmembrane sequences
Homo sapiens
16020
-
mitochondrion
-
Homo sapiens
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
decaprenyl diphosphate + 4-hydroxybenzoate
Saccharomyces cerevisiae
-
diphosphate + decaprenyl-4-hydroxybenzoate
-
-
?
decaprenyl diphosphate + 4-hydroxybenzoate
Homo sapiens
-
diphosphate + decaprenyl-4-hydroxybenzoate
-
-
?
additional information
Saccharomyces cerevisiae
the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone
?
-
-
?
additional information
Homo sapiens
the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone
?
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
Saccharomyces cerevisiae
-
diphosphate + nonaprenyl-4-hydroxybenzoate
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
Homo sapiens
-
diphosphate + nonaprenyl-4-hydroxybenzoate
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adrenal gland
high enzyme expression
Homo sapiens
-
brain
fetal
Homo sapiens
-
heart
high enzyme expression
Homo sapiens
-
liver
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
skeletal muscle
high enzyme expression
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
activity in recombinant yeast cells
Saccharomyces cerevisiae
additional information
-
activity in recombinant yeast cells
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
decaprenyl diphosphate + 4-hydroxybenzoate
-
657846
Saccharomyces cerevisiae
diphosphate + decaprenyl-4-hydroxybenzoate
-
-
-
?
decaprenyl diphosphate + 4-hydroxybenzoate
-
657846
Homo sapiens
diphosphate + decaprenyl-4-hydroxybenzoate
-
-
-
?
decaprenyl diphosphate + 4-hydroxybenzoate
preferred substrate
657846
Homo sapiens
diphosphate + decaprenyl-4-hydroxybenzoate
-
-
-
?
additional information
the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone
657846
Saccharomyces cerevisiae
?
-
-
-
?
additional information
the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone
657846
Homo sapiens
?
-
-
-
?
additional information
the enzyme catalyzes the prenylation of 4-hydroxybenzoate with an all-trans polyprenyl group
657846
Saccharomyces cerevisiae
?
-
-
-
?
additional information
the enzyme catalyzes the prenylation of 4-hydroxybenzoate with an all-trans polyprenyl group
657846
Homo sapiens
?
-
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
-
657846
Saccharomyces cerevisiae
diphosphate + nonaprenyl-4-hydroxybenzoate
-
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
-
657846
Homo sapiens
diphosphate + nonaprenyl-4-hydroxybenzoate
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
More
the enzyme contains 6 transmembrane sequences and an UbiA domain
Homo sapiens
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Saccharomyces cerevisiae
30
-
assay at
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Saccharomyces cerevisiae
7.4
-
assay at
Homo sapiens
Other publictions for EC 2.5.1.39
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
759945
Liu
SmPPT, a 4-hydroxybenzoate po ...
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1527-1540
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1
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11
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2
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760056
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-
Site-directed mutagenesis of ...
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Proc. Biochem.
58
186-192
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7
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1
1
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728802
Cheng
Structural insights into ubiqu ...
Aeropyrum pernix, Aeropyrum pernix DSM 11879
Science
343
878-881
2014
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738168
Scalais
Early myoclonic epilepsy, hype ...
Homo sapiens
Eur. J. Paediatr. Neurol.
17
625-630
2013
-
-
1
-
1
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-
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2
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5
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5
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1
1
-
-
-
723550
Quinzii
Effects of inhibiting CoQ10 bi ...
Homo sapiens
PLoS ONE
7
e30606
2012
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1
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2
2
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723246
Forsman
4-Nitrobenzoate inhibits coenz ...
Mus musculus
Nat. Chem. Biol.
6
515-517
2010
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1
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1
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3
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1
1
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703208
Bräuer
A structural model of the memb ...
Escherichia coli
Chembiochem
9
982-992
2008
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1
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5
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1
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5
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1
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5
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1
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1
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703609
Quinzii
Respiratory chain dysfunction ...
Homo sapiens
FASEB J.
22
1874-1885
2008
-
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2
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1
1
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674978
Zhang
Phenotypes and fed-batch ferme ...
Schizosaccharomyces pombe, Schizosaccharomyces pombe SPQ-01
J. Biotechnol.
128
120-131
2007
-
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2
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7
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675069
Mollet
Prenyldiphosphate synthase, su ...
Homo sapiens
J. Clin. Invest.
117
765-772
2007
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5
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1
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687033
Lopez-Martin
Missense mutation of the COQ2 ...
Saccharomyces cerevisiae, Homo sapiens
Hum. Mol. Genet.
16
1091-1097
2007
-
1
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2
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2
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705592
Tran
Endogenous synthesis of coenzy ...
Arabidopsis thaliana, Oryza sativa, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Rattus norvegicus
Mitochondrion
7
62-71
2007
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1
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5
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738464
Diomedi-Camassei
COQ2 nephropathy: a newly desc ...
Homo sapiens
J. Am. Soc. Nephrol.
18
2773-2780
2007
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1
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3
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1
1
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671299
Buron
Stimulation of polyprenyl 4-hy ...
Homo sapiens
Anal. Biochem.
353
15-21
2006
4
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1
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676467
Ohara
Functional characterization of ...
Oryza sativa
Plant Cell Physiol.
47
581-590
2006
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1
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7
2
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1
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6
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3
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3
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The AtPPT1 gene encoding 4-hyd ...
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Modeling the E. coli 4-hydroxy ...
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3
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637004
Tekle
Ubiquinone biosynthesis in rat ...
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2002
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1
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637002
Boehm
Active expression of the ubiA ...
Escherichia coli
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2000
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1
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637005
Uchida
Phenotypes of fission yeast de ...
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2000
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Wessjohann
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Prenylation of benzoic acid de ...
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703082
Olsson
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Enzymes of the mevalonate path ...
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705488
Andersson
Age-dependent modifications in ...
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1995
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637003
Melzer
Characterization of polyprenyl ...
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Biochim. Biophys. Acta
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1994
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4
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Nichols
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Kawahara
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Partial purification and chara ...
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Uchida
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Solubilization of 4-hydroxyben ...
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Kalen
Nonaprenyl-4-hydroxybenzoate t ...
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J. Biol. Chem.
265
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1990
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Gupta
4-Hydroxybenzoate polyprenyltr ...
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Methods Enzymol.
110
327-334
1985
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Nishino
Effects of detergents on the p ...
Cavia porcellus, Rattus norvegicus
Biochemistry
16
605-609
1977
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10
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6
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Young
Biochemical and genetic studie ...
Escherichia coli
J. Bacteriol.
110
18-25
1972
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