Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.34 extracted from

  • Shibuya, M.; Chou, H.M.; Fountoulakis, M.; Hassam, S.; Kim, S.U.; Kobayashi, K.; Otsuka, H.; Rogalska, E.; Cassady, J.M.; Floss, H.G.
    Stereochemistry of the isoprenylation of tryptophan catalyzed by 4-(gamma,gamma-dimethylallyl)tryptophan synthase from Claviceps, the first pathway-specific enzyme in ergot alkaloid biosynthesis (1990), J. Am. Chem. Soc., 112, 297-304.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dimethylallyl diphosphate + L-tryptophan Claviceps sp. first pathway-specific enzyme of ergot alkaloid biosynthesis diphosphate + L-4-(gamma,gamma-dimethylallyl)tryptophan
-
?

Organism

Organism UniProt Comment Textmining
Claviceps sp.
-
-
-

Reaction

Reaction Comment Organism Reaction ID
dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan stereochemistry, direct attack of dimethylallyl diphosphate on C-4 of the indole Claviceps sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dimethylallyl diphosphate + L-tryptophan
-
Claviceps sp. diphosphate + L-4-(gamma,gamma-dimethylallyl)tryptophan
-
?
dimethylallyl diphosphate + L-tryptophan first pathway-specific enzyme of ergot alkaloid biosynthesis Claviceps sp. diphosphate + L-4-(gamma,gamma-dimethylallyl)tryptophan
-
?