Application | Comment | Organism |
---|---|---|
pharmacology | target for the development of antibacterials | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1-hydroxy-2-phenylethane-1,1-diyl)bis(phosphonic acid) | - |
Escherichia coli | |
(1-hydroxy-2-[3'-[(naphthalene-2-sulfonyl)amino][1,1'-biphenyl]-3-yl]ethane-1,1-diyl)bis(phosphonic acid) | - |
Escherichia coli | |
(2Z)-2-hydroxy-4-oxo-4-[[3-(3-phenoxyphenyl)propyl]amino]but-2-enoic acid | - |
Escherichia coli | |
(2Z)-2-hydroxy-4-[3-[3-(octyloxy)phenoxy]phenyl]-4-oxobut-2-enoic acid | - |
Escherichia coli | |
(2Z)-2-hydroxy-4-[4-(octyloxy)phenyl]-4-oxobut-2-enoic acid | - |
Escherichia coli | |
(2Z)-4-([3-[3-(hexyloxy)phenyl]propyl]amino)-2-hydroxy-4-oxobut-2-enoic acid | - |
Escherichia coli | |
(2Z)-4-[3-[3-(decyloxy)phenoxy]phenyl]-2-hydroxy-4-oxobut-2-enoic acid | - |
Escherichia coli | |
(2Z)-4-[[3-([1,1'-biphenyl]-3-yl)propyl]amino]-2-hydroxy-4-oxobut-2-enoic acid | - |
Escherichia coli | |
1-(2-hydroxy-2,2-diphosphonoethyl)-3-phenylpyridin-1-ium | - |
Escherichia coli | |
1-[[3-(hexyloxy)phenyl]methyl]-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid | - |
Escherichia coli | |
2-hydroxy-6-(undecyloxy)benzoic acid | - |
Escherichia coli | |
2-[4-[(E)-2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethylethan-1-amine | - |
Escherichia coli | |
2-[[3-(3,4-dimethylphenoxy)phenyl]carbamoyl]benzoic acid | - |
Escherichia coli | |
3-(2-chlorophenyl)-5-methyl-N-[4-(propan-2-yl)phenyl]-1,2-oxazole-4-carboxamide | - |
Escherichia coli | |
3-(4-chlorophenyl)-N'-[(2,4-dihydroxyphenyl)methyl]-1H-pyrazole-5-carbohydrazide | - |
Escherichia coli | |
3-(dibenzo[b,d]furan-4-yl)-1-(2,2-diphosphonoethyl)pyridin-1-ium | - |
Escherichia coli | |
3-([1,1'-biphenyl]-2-yl)-1-(2,2-diphosphonoethyl)pyridin-1-ium | - |
Escherichia coli | |
3-([1,1'-biphenyl]-3-yl)-1-(2,2-diphosphonoethyl)pyridin-1-ium | - |
Escherichia coli | |
3-([1,1'-biphenyl]-3-yl)-1-(2-hydroxy-2,2-diphosphonoethyl)pyridin-1-ium | - |
Escherichia coli | |
3-([1,1'-biphenyl]-4-yl)-1-(2,2-diphosphonoethyl)pyridin-1-ium | - |
Escherichia coli | |
3-fluoro-1-(2-hydroxy-2,2-diphosphonoethyl)pyridin-1-ium | - |
Escherichia coli | |
3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1-(2,2-diphosphonoethyl)pyridin-1-ium | - |
Escherichia coli | |
3-[(5Z)-5-[[5-(2,4-dichlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid | - |
Escherichia coli | |
4-(dibenzo[b,d]furan-4-yl)-1-(2-hydroxy-2,2-diphosphonoethyl)pyridin-1-ium | - |
Escherichia coli | |
4-([1,1'-biphenyl]-3-yl)-1-(2,2-diphosphonoethyl)pyridin-1-ium | - |
Escherichia coli | |
4-([1,1'-biphenyl]-4-yl)-1-(2,2-diphosphonoethyl)pyridin-1-ium | - |
Escherichia coli | |
4-[3-[([1,1'-biphenyl]-4-carbonyl)amino]phenoxy]benzene-1,2-dicarboxylic acid | - |
Escherichia coli | |
5-([5-[(1H-benzimidazol-2-yl)sulfanyl]furan-2-yl]methylidene)-1,3-diazinane-2,4,6-trione | - |
Escherichia coli | |
5-benzyl-3-[1-(4-cyclohexylanilino)ethenyl]-4-hydroxy-5,6-dihydropyridin-2(1H)-one | - |
Escherichia coli | |
5-benzyl-4-hydroxy-3-[1-[4-(1H-imidazol-1-yl)anilino]ethenyl]-5,6-dihydropyridin-2(1H)-one | - |
Escherichia coli | |
5-benzyl-N-(4-cyclohexylphenyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide | - |
Escherichia coli | |
5-benzyl-N-[4-(hexyloxy)phenyl]-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide | - |
Escherichia coli | |
5-bromo-2-[4-(6-chloro-2,3-dihydro-1H-indole-1-sulfonyl)benzamido]benzoic acid | - |
Escherichia coli | |
6-benzyl-4-hydroxy-3-[1-[4-(1H-imidazol-1-yl)anilino]ethenyl]-5,6-dihydropyridin-2(1H)-one | - |
Escherichia coli | |
N-(3,5-dichlorophenyl)-4-hydroxy-2-oxo-5-phenyl-2,5-dihydro-1H-pyrrole-3-carboxamide | - |
Escherichia coli | |
N-(4-chlorophenyl)-4-hydroxy-2-oxo-5-phenyl-2,5-dihydro-1H-pyrrole-3-carboxamide | - |
Escherichia coli | |
N-(4-cyclohexylphenyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide | - |
Escherichia coli | |
N-(4-cyclohexylphenyl)-4-hydroxy-2-oxo-5-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-3-carboxamide | - |
Escherichia coli | |
N-(4-cyclohexylphenyl)-4-hydroxy-2-oxo-5-phenyl-2,5-dihydro-1H-pyrrole-3-carboxamide | - |
Escherichia coli | |
N-([1,1'-biphenyl]-4-yl)-4-hydroxy-2-oxo-5-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-3-carboxamide | - |
Escherichia coli | |
N-[3-[3,4-di(prop-1-en-2-yl)phenoxy]phenyl][1,1'-biphenyl]-4-carboxamide | - |
Escherichia coli | |
N1,N4-bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-2-nitrobenzene-1,4-dicarboxamide | - |
Escherichia coli | |
[(5Z)-5-[[5-(4-chloro-2-methylphenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid | - |
Escherichia coli | |
[1-hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid) | - |
Escherichia coli | |
[1-hydroxy-2-([1(1),2(1):2(3),3(1)-terphenyl]-1(3)-yl)ethane-1,1-diyl]bis(phosphonic acid) | - |
Escherichia coli | |
[1-hydroxy-2-([1(1),2(1):2(3),3(1)-terphenyl]-1(4)-yl)ethane-1,1-diyl]bis(phosphonic acid) | - |
Escherichia coli | |
[1-hydroxy-2-([1(1),2(1):2(4),3(1)-terphenyl]-1(3)-yl)ethane-1,1-diyl]bis(phosphonic acid) | - |
Escherichia coli | |
[1-hydroxy-2-[([1(1),2(1):2(3),3(1)-terphenyl]-1(3)-yl)oxy]ethane-1,1-diyl]bis(phosphonic acid) | - |
Escherichia coli | |
[1-hydroxy-3-([1(1),2(1):2(2),3(1)-terphenyl]-1(3)-yl)propane-1,1-diyl]bis(phosphonic acid) | - |
Escherichia coli | |
[1-hydroxy-3-([1(1),2(1):2(3),3(1)-terphenyl]-1(3)-yl)propane-1,1-diyl]bis(phosphonic acid) | - |
Escherichia coli | |
[1-hydroxy-3-([1(1),2(1):2(4),3(1)-terphenyl]-1(3)-yl)propane-1,1-diyl]bis(phosphonic acid) | - |
Escherichia coli | |
[2-([1,1'-biphenyl]-3-yl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid) | - |
Escherichia coli | |
[2-[3-(dibenzo[b,d]furan-4-yl)phenyl]-1-hydroxyethane-1,1-diyl]bis(phosphonic acid) | - |
Escherichia coli | |
[3-(3,4-dichlorophenyl)-4,5-dihydro-1,2-oxazole-5,5-diyl]bis(phosphonic acid) | - |
Escherichia coli | |
[3-[4-(dibenzo[b,d]furan-4-yl)phenyl]-1-hydroxypropane-1,1-diyl]bis(phosphonic acid) | - |
Escherichia coli | |
[4-([1,1'-biphenyl]-4-yl)butane-1,1-diyl]bis(phosphonic acid) | - |
Escherichia coli | |
[hydroxy([1(1),2(1):2(3),3(1)-terphenyl]-1(3)-yl)methylene]bis(phosphonic acid) | - |
Escherichia coli | |
[[(9-ethyl-9H-carbazol-3-yl)amino](hydroxy)methylene]bis(phosphonic acid) | - |
Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P60472 | - |
- |
Escherichia coli K12 | P60472 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
undecaprenyl pyrophosphate synthase | - |
Escherichia coli |
UPPs | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00004 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 5-benzyl-3-[1-(4-cyclohexylanilino)ethenyl]-4-hydroxy-5,6-dihydropyridin-2(1H)-one | |
0.00012 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | N-([1,1'-biphenyl]-4-yl)-4-hydroxy-2-oxo-5-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-3-carboxamide | |
0.00016 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | N-(4-cyclohexylphenyl)-4-hydroxy-2-oxo-5-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-3-carboxamide | |
0.00024 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | (2Z)-4-[[3-([1,1'-biphenyl]-3-yl)propyl]amino]-2-hydroxy-4-oxobut-2-enoic acid | |
0.0005 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | (2Z)-2-hydroxy-4-[3-[3-(octyloxy)phenoxy]phenyl]-4-oxobut-2-enoic acid | |
0.0005 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 5-benzyl-N-(4-cyclohexylphenyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide | |
0.00051 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | (2Z)-2-hydroxy-4-[4-(octyloxy)phenyl]-4-oxobut-2-enoic acid | |
0.00056 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | (2Z)-4-([3-[3-(hexyloxy)phenyl]propyl]amino)-2-hydroxy-4-oxobut-2-enoic acid | |
0.00059 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [2-[3-(dibenzo[b,d]furan-4-yl)phenyl]-1-hydroxyethane-1,1-diyl]bis(phosphonic acid) | |
0.00063 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 5-benzyl-4-hydroxy-3-[1-[4-(1H-imidazol-1-yl)anilino]ethenyl]-5,6-dihydropyridin-2(1H)-one | |
0.00069 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [1-hydroxy-2-([1(1),2(1):2(3),3(1)-terphenyl]-1(3)-yl)ethane-1,1-diyl]bis(phosphonic acid) | |
0.00091 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [1-hydroxy-2-([1(1),2(1):2(4),3(1)-terphenyl]-1(3)-yl)ethane-1,1-diyl]bis(phosphonic acid) | |
0.001 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 5-bromo-2-[4-(6-chloro-2,3-dihydro-1H-indole-1-sulfonyl)benzamido]benzoic acid | |
0.0011 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | (1-hydroxy-2-[3'-[(naphthalene-2-sulfonyl)amino][1,1'-biphenyl]-3-yl]ethane-1,1-diyl)bis(phosphonic acid) | |
0.0013 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [1-hydroxy-2-[([1(1),2(1):2(3),3(1)-terphenyl]-1(3)-yl)oxy]ethane-1,1-diyl]bis(phosphonic acid) | |
0.0018 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [hydroxy([1(1),2(1):2(3),3(1)-terphenyl]-1(3)-yl)methylene]bis(phosphonic acid) | |
0.0019 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | (2Z)-4-[3-[3-(decyloxy)phenoxy]phenyl]-2-hydroxy-4-oxobut-2-enoic acid | |
0.002 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | N-(3,5-dichlorophenyl)-4-hydroxy-2-oxo-5-phenyl-2,5-dihydro-1H-pyrrole-3-carboxamide | |
0.002 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [1-hydroxy-2-([1(1),2(1):2(3),3(1)-terphenyl]-1(4)-yl)ethane-1,1-diyl]bis(phosphonic acid) | |
0.0022 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | (2Z)-2-hydroxy-4-oxo-4-[[3-(3-phenoxyphenyl)propyl]amino]but-2-enoic acid | |
0.0022 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 2-hydroxy-6-(undecyloxy)benzoic acid | |
0.0031 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [1-hydroxy-3-([1(1),2(1):2(2),3(1)-terphenyl]-1(3)-yl)propane-1,1-diyl]bis(phosphonic acid) | |
0.0032 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 4-[3-[([1,1'-biphenyl]-4-carbonyl)amino]phenoxy]benzene-1,2-dicarboxylic acid | |
0.0032 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | N-[3-[3,4-di(prop-1-en-2-yl)phenoxy]phenyl][1,1'-biphenyl]-4-carboxamide | |
0.0035 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | N-(4-cyclohexylphenyl)-4-hydroxy-2-oxo-5-phenyl-2,5-dihydro-1H-pyrrole-3-carboxamide | |
0.0048 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | N1,N4-bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-2-nitrobenzene-1,4-dicarboxamide | |
0.0055 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [1-hydroxy-3-([1(1),2(1):2(3),3(1)-terphenyl]-1(3)-yl)propane-1,1-diyl]bis(phosphonic acid) | |
0.0068 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [2-([1,1'-biphenyl]-3-yl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid) | |
0.0078 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [[(9-ethyl-9H-carbazol-3-yl)amino](hydroxy)methylene]bis(phosphonic acid) | |
0.0088 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 6-benzyl-4-hydroxy-3-[1-[4-(1H-imidazol-1-yl)anilino]ethenyl]-5,6-dihydropyridin-2(1H)-one | |
0.01 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 3-([1,1'-biphenyl]-3-yl)-1-(2-hydroxy-2,2-diphosphonoethyl)pyridin-1-ium | |
0.01 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [1-hydroxy-3-([1(1),2(1):2(4),3(1)-terphenyl]-1(3)-yl)propane-1,1-diyl]bis(phosphonic acid) | |
0.012 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [3-[4-(dibenzo[b,d]furan-4-yl)phenyl]-1-hydroxypropane-1,1-diyl]bis(phosphonic acid) | |
0.013 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 4-(dibenzo[b,d]furan-4-yl)-1-(2-hydroxy-2,2-diphosphonoethyl)pyridin-1-ium | |
0.019 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 5-benzyl-N-[4-(hexyloxy)phenyl]-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide | |
0.021 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 4-([1,1'-biphenyl]-3-yl)-1-(2,2-diphosphonoethyl)pyridin-1-ium | |
0.024 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | N-(4-chlorophenyl)-4-hydroxy-2-oxo-5-phenyl-2,5-dihydro-1H-pyrrole-3-carboxamide | |
0.027 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 1-[[3-(hexyloxy)phenyl]methyl]-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid | |
0.028 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 4-([1,1'-biphenyl]-4-yl)-1-(2,2-diphosphonoethyl)pyridin-1-ium | |
0.034 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 3-(dibenzo[b,d]furan-4-yl)-1-(2,2-diphosphonoethyl)pyridin-1-ium | |
0.035 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 3-([1,1'-biphenyl]-4-yl)-1-(2,2-diphosphonoethyl)pyridin-1-ium | |
0.048 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 1-(2-hydroxy-2,2-diphosphonoethyl)-3-phenylpyridin-1-ium | |
0.058 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | N-(4-cyclohexylphenyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide | |
0.068 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 3-([1,1'-biphenyl]-3-yl)-1-(2,2-diphosphonoethyl)pyridin-1-ium | |
0.069 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [4-([1,1'-biphenyl]-4-yl)butane-1,1-diyl]bis(phosphonic acid) | |
0.087 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [3-(3,4-dichlorophenyl)-4,5-dihydro-1,2-oxazole-5,5-diyl]bis(phosphonic acid) | |
0.089 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1-(2,2-diphosphonoethyl)pyridin-1-ium | |
0.12 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 3-([1,1'-biphenyl]-2-yl)-1-(2,2-diphosphonoethyl)pyridin-1-ium | |
0.15 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 2-[[3-(3,4-dimethylphenoxy)phenyl]carbamoyl]benzoic acid | |
0.2 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | (1-hydroxy-2-phenylethane-1,1-diyl)bis(phosphonic acid) | |
0.49 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | 3-fluoro-1-(2-hydroxy-2,2-diphosphonoethyl)pyridin-1-ium | |
0.66 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Escherichia coli | [1-hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid) |
General Information | Comment | Organism |
---|---|---|
metabolism | essential enzyme in the biosynthesis of the bacterial cell wall | Escherichia coli |