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Literature summary for 2.5.1.31 extracted from
- A small-molecule screening platform for the discovery of inhibitors of undecaprenyl diphosphate synthase (2016), ACS Infect. Dis., 2, 489-499 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Staphylococcus aureus |
- |
Escherichia coli |
- |
Bacillus subtilis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-[3-fluoro-4-(4-[[2-(thiophen-2-yl)-1,3-thiazol-4-yl]methyl]piperazin-1-yl)phenyl]ethan-1-one | - |
Bacillus subtilis |  |
| 2,6-bis(5-bromo-2-hydroxyphenyl)-3,5-dimethylpiperidin-4-one | - |
Bacillus subtilis | |
| 3-ethoxy-2-methyl-6-(4-phenyl-1H-pyrazol-3-yl)phenol | - |
Bacillus subtilis | |
| 4-(benzyloxy)-3-bromo-5-methoxy-N-[(oxolan-2-yl)methyl]benzamide | - |
Bacillus subtilis | |
| 7-(azepan-1-yl)-3-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidine | - |
Bacillus subtilis | |
| MAC-0110792 | - |
Escherichia coli | |
| MAC-0547630 | the inhibitor shows great promise as a whole cell-active probe due to its selective and potent inhibition of undecaprenyl diphosphate synthase | Bacillus subtilis | |
| MAC-0547630 | the inhibitor shows great promise as a whole cell-active probe due to its selective and potent inhibition of undecaprenyl diphosphate synthase | Escherichia coli | |
| MAC-0547630 | the inhibitor shows great promise as a whole cell-active probe due to its selective and potent inhibition of undecaprenyl diphosphate synthase | Staphylococcus aureus | |
| MAC-0557874 | - |
Bacillus subtilis | |
| MAC-0557874 | - |
Escherichia coli | |
| MAC-0557874 | - |
Staphylococcus aureus | |
| MAC-0588238 | - |
Bacillus subtilis | |
| MAC-0588238 | - |
Staphylococcus aureus | |
| MAC-0602693 | - |
Bacillus subtilis | |
| MAC-0602693 | - |
Staphylococcus aureus | |
| additional information | a small-molecule screening platform for the discovery of inhibitors of undecaprenyl diphosphate synthase; small-molecule screening platform for the discovery of inhibitors of undecaprenyl diphosphate synthase | Bacillus subtilis | |
| additional information | a small-molecule screening platform for the discovery of inhibitors of undecaprenyl diphosphate synthase | Escherichia coli | |
| additional information | a small-molecule screening platform for the discovery of inhibitors of undecaprenyl diphosphate synthase | Staphylococcus aureus | |
| targocil | - |
Bacillus subtilis | |
| targocil | - |
Escherichia coli | |
| targocil | - |
Staphylococcus aureus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | Staphylococcus aureus | - |
8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | Escherichia coli | - |
8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | Bacillus subtilis | - |
8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | Bacillus subtilis 168 | - |
8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | Staphylococcus aureus Newman | - |
8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | Staphylococcus aureus USA300 | - |
8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | Escherichia coli K12 | - |
8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | O31751 | - |
- |
| Bacillus subtilis 168 | O31751 | - |
- |
| Escherichia coli | - |
BW25113 | - |
| Escherichia coli | P60472 | BW 25113 | - |
| Escherichia coli K12 | - |
BW25113 | - |
| Escherichia coli K12 | P60472 | BW 25113 | - |
| Staphylococcus aureus | - |
- |
- |
| Staphylococcus aureus | A0A0H2XGF2 | - |
- |
| Staphylococcus aureus Newman | - |
- |
- |
| Staphylococcus aureus USA300 | A0A0H2XGF2 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | - |
Staphylococcus aureus | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | - |
Escherichia coli | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | - |
Bacillus subtilis | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | the enzyme catalyzes the synthesis of the C55 lipid undecaprenyl diphosphate through eight consecutive condensations of isopentenyl pyrophosphate | Staphylococcus aureus | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | the enzyme catalyzes the synthesis of the C55 lipid undecaprenyl diphosphate through eight consecutive condensations of isopentenyl pyrophosphate | Escherichia coli | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | the enzyme catalyzes the synthesis of the C55 lipid undecaprenyl diphosphate through eight consecutive condensations of isopentenyl pyrophosphate | Bacillus subtilis | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | - |
Bacillus subtilis 168 | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | the enzyme catalyzes the synthesis of the C55 lipid undecaprenyl diphosphate through eight consecutive condensations of isopentenyl pyrophosphate | Bacillus subtilis 168 | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | - |
Staphylococcus aureus Newman | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | the enzyme catalyzes the synthesis of the C55 lipid undecaprenyl diphosphate through eight consecutive condensations of isopentenyl pyrophosphate | Staphylococcus aureus Newman | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | - |
Staphylococcus aureus USA300 | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | - |
Escherichia coli K12 | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | the enzyme catalyzes the synthesis of the C55 lipid undecaprenyl diphosphate through eight consecutive condensations of isopentenyl pyrophosphate | Escherichia coli K12 | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Staphylococcus aureus |
| homodimer | - |
Escherichia coli |
| homodimer | - |
Bacillus subtilis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| undecaprenyl diphosphate synthase | - |
Staphylococcus aureus |
| undecaprenyl diphosphate synthase | - |
Escherichia coli |
| undecaprenyl diphosphate synthase | - |
Bacillus subtilis |
| UPPs | - |
Staphylococcus aureus |
| UPPs | - |
Escherichia coli |
| UPPs | - |
Bacillus subtilis |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00005 | - |
pH and temperature not specified in the publication | Bacillus subtilis | MAC-0547630 | |
| 0.00005 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Bacillus subtilis | 7-(azepan-1-yl)-3-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidine | |
| 0.0013 | - |
pH and temperature not specified in the publication | Bacillus subtilis | MAC-0588238 | |
| 0.0013 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Bacillus subtilis | 4-(benzyloxy)-3-bromo-5-methoxy-N-[(oxolan-2-yl)methyl]benzamide | |
| 0.00139 | - |
pH and temperature not specified in the publication | Escherichia coli | MAC-0557874 | |
| 0.00139 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Bacillus subtilis | 2,6-bis(5-bromo-2-hydroxyphenyl)-3,5-dimethylpiperidin-4-one | |
| 0.0016 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | MAC-0547630 | |
| 0.0016 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Bacillus subtilis | 7-(azepan-1-yl)-3-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidine | |
| 0.00622 | - |
pH and temperature not specified in the publication | Bacillus subtilis | MAC-0557874 | |
| 0.00622 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Bacillus subtilis | 2,6-bis(5-bromo-2-hydroxyphenyl)-3,5-dimethylpiperidin-4-one | |
| 0.01166 | - |
pH and temperature not specified in the publication | Escherichia coli | MAC-0110792 | |
| 0.01166 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Bacillus subtilis | 3-ethoxy-2-methyl-6-(4-phenyl-1H-pyrazol-3-yl)phenol | |
| 0.038 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | MAC-0588238 | |
| 0.038 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Bacillus subtilis | 4-(benzyloxy)-3-bromo-5-methoxy-N-[(oxolan-2-yl)methyl]benzamide | |
| 0.0397 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | MAC-0557874 | |
| 0.042 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Bacillus subtilis | 2,6-bis(5-bromo-2-hydroxyphenyl)-3,5-dimethylpiperidin-4-one | |
| 0.0429 | - |
pH and temperature not specified in the publication | Bacillus subtilis | MAC-0602693 | |
| 0.0429 | - |
pH and temperature not specified in the publication, mutant enzyme Y246D | Bacillus subtilis | 1-[3-fluoro-4-(4-[[2-(thiophen-2-yl)-1,3-thiazol-4-yl]methyl]piperazin-1-yl)phenyl]ethan-1-one | |
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