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Literature summary for 2.5.1.31 extracted from

  • Wang, Y.; Desai, J.; Zhang, Y.; Malwal, S.R.; Shin, C.J.; Feng, X.; Sun, H.; Liu, G.; Guo, R.T.; Oldfield, E.
    Bacterial cell growth inhibitors targeting undecaprenyl diphosphate synthase and undecaprenyl diphosphate phosphatase (2016), ChemMedChem, 11, 2311-2319 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.31

Application

Application Comment Organism
pharmacology the enzyme is an attractive drug target since it is not used by humans Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
(5-bromo-2-[[3-(octyloxy)phenyl]methoxy]phenyl)phosphonic acid
-
 Staphylococcus aureus
2-methoxy-6-[3-(octyloxy)benzamido]benzoic acid
-
 Staphylococcus aureus
2-[3-(decyloxy)benzamido]-5-nitrobenzoic acid
-
 Staphylococcus aureus
2-[3-(hexyloxy)benzamido]benzoic acid
-
 Staphylococcus aureus
2-[3-(octyloxy)benzamido]-5-(trifluoromethoxy)benzoic acid
-
 Staphylococcus aureus
2-[3-(octyloxy)benzamido]-5-phosphonobenzoic acid
-
 Staphylococcus aureus
2-[3-(octyloxy)benzamido]benzoic acid
-
 Staphylococcus aureus
2-[methyl[3-(octyloxy)benzoyl]amino]benzoic acid
-
 Staphylococcus aureus
3-[3-(hexyloxy)benzamido]-4-hydroxybenzoic acid
-
 Staphylococcus aureus
3-[3-(octyloxy)benzamido]benzene-1,2-dicarboxylic acid
-
 Staphylococcus aureus
4,5-difluoro-2-[3-(octyloxy)benzamido]benzoic acid
-
 Staphylococcus aureus
4-[3-(octyloxy)benzamido]benzene-1,3-dicarboxylic acid
-
 Staphylococcus aureus
5-(diethoxyphosphoryl)-2-[3-(octyloxy)benzamido]benzoic acid
-
 Staphylococcus aureus
5-(methanesulfonyl)-2-[3-(octyloxy)benzamido]benzoic acid
-
 Staphylococcus aureus
5-bromo-2-[3-(3,3-dimethylbut-1-yn-1-yl)benzamido]benzoic acid
-
 Staphylococcus aureus
5-bromo-2-[3-(octyloxy)benzamido]benzoic acid
-
 Staphylococcus aureus
5-chloro-2-[3-(octyloxy)benzamido]benzoic acid
-
 Staphylococcus aureus
5-fluoro-2-[3-(hexyloxy)benzamido]benzoic acid
-
 Staphylococcus aureus
5-fluoro-2-[3-(octyloxy)benzamido]benzoic acid
-
 Staphylococcus aureus
5-hydroxy-2-[3-(octyloxy)benzamido]benzoic acid
-
 Staphylococcus aureus
5-methoxy-2-[3-(octyloxy)benzamido]benzoic acid
-
 Staphylococcus aureus
5-methoxy-4-(2-methoxyethoxy)-2-[3-(octyloxy)benzamido]benzoic acid
-
 Staphylococcus aureus
5-[3-(octyloxy)benzamido]benzene-1,3-dicarboxylic acid
-
 Staphylococcus aureus
N-(2-carbamoylphenyl)-3-(octyloxy)benzamide
-
 Staphylococcus aureus
N-(4-bromo-2-carbamoylphenyl)-3,4-bis(2-methoxyethoxy)benzamide
-
 Staphylococcus aureus
[2-[3-(octyloxy)benzamido]phenyl]phosphonic acid
-
 Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Synonyms

Synonyms Comment Organism
undecaprenyl diphosphate phosphatase
-
 Staphylococcus aureus
UPPs
-
 Staphylococcus aureus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00032
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 5-fluoro-2-[3-(octyloxy)benzamido]benzoic acid
0.00033
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 5-fluoro-2-[3-(octyloxy)benzamido]benzoic acid
0.00054
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 5-bromo-2-[3-(octyloxy)benzamido]benzoic acid
0.0006
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 5-chloro-2-[3-(octyloxy)benzamido]benzoic acid
0.00078
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 2-[3-(octyloxy)benzamido]-5-(trifluoromethoxy)benzoic acid
0.00096
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 4,5-difluoro-2-[3-(octyloxy)benzamido]benzoic acid
0.0013
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 5-hydroxy-2-[3-(octyloxy)benzamido]benzoic acid
0.0013
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 5-methoxy-2-[3-(octyloxy)benzamido]benzoic acid
0.0016
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 2-[3-(octyloxy)benzamido]benzoic acid
0.002
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 5-(methanesulfonyl)-2-[3-(octyloxy)benzamido]benzoic acid
0.0024
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 2-[3-(hexyloxy)benzamido]benzoic acid
0.0025
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus (5-bromo-2-[[3-(octyloxy)phenyl]methoxy]phenyl)phosphonic acid
0.003
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 2-[3-(octyloxy)benzamido]-5-phosphonobenzoic acid
0.0032
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 5-(diethoxyphosphoryl)-2-[3-(octyloxy)benzamido]benzoic acid
0.0034
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 5-(diethoxyphosphoryl)-2-[3-(octyloxy)benzamido]benzoic acid
0.0045
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 3-[3-(octyloxy)benzamido]benzene-1,2-dicarboxylic acid
0.0049
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 5-fluoro-2-[3-(hexyloxy)benzamido]benzoic acid
0.0049
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 2-[3-(decyloxy)benzamido]-5-nitrobenzoic acid
0.0049
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 3-[3-(hexyloxy)benzamido]-4-hydroxybenzoic acid
0.006
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 2-methoxy-6-[3-(octyloxy)benzamido]benzoic acid
0.0069
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 5-bromo-2-[3-(3,3-dimethylbut-1-yn-1-yl)benzamido]benzoic acid
0.007
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 5-[3-(octyloxy)benzamido]benzene-1,3-dicarboxylic acid
0.008
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 2-[methyl[3-(octyloxy)benzoyl]amino]benzoic acid
0.0085
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 4-[3-(octyloxy)benzamido]benzene-1,3-dicarboxylic acid
0.01
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus 5-methoxy-4-(2-methoxyethoxy)-2-[3-(octyloxy)benzamido]benzoic acid
0.039
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus [2-[3-(octyloxy)benzamido]phenyl]phosphonic acid
0.06
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus N-(2-carbamoylphenyl)-3-(octyloxy)benzamide
0.13
-
 pH and temperature not specified in the publication, mutant enzyme Y246D Staphylococcus aureus N-(4-bromo-2-carbamoylphenyl)-3,4-bis(2-methoxyethoxy)benzamide