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Literature summary for 2.5.1.31 extracted from

  • Lee, L.V.; Granda, B.; Dean, K.; Tao, J.; Liu, E.; Zhang, R.; Peukert, S.; Wattanasin, S.; Xie, X.; Ryder, N.S.; Tommasi, R.; Deng, G.
    Biophysical investigation of the mode of inhibition of tetramic acids, the allosteric inhibitors of undecaprenyl pyrophosphate synthase (2010), Biochemistry, 49, 5366-5376.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.31

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Streptococcus pneumoniae

Inhibitors

Inhibitors Comment Organism Structure
(2E,6E)-farnesyl thiodiphosphate substrate analogue Streptococcus pneumoniae
(4aS,8aS)-4-hydroxy-2-oxo-1,2,4a,5,6,7,8,8a-octahydro[1,6]naphthyridine-3-carboxylic acid (4-piperidin-1-ylphenyl)amide
-
 Streptococcus pneumoniae
5-benzyl-4-hydroxy-5-methyl-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid (4-cyclohexylphenyl)amide
-
 Streptococcus pneumoniae
isopentyl thiodiphosphate substrate analogue Streptococcus pneumoniae
additional information tetramic acids are selective and potent inhibitors of UPPS Streptococcus pneumoniae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptococcus pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate
-
 Streptococcus pneumoniae 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate
-
 ?
N-(4-benzoylphenyl)-4-hydroxy-2-oxo-5-phenethyl-2,5-dihydro-1H-pyrrole-3-carboxamide + isopentenyl diphosphate Photo-probe Streptococcus pneumoniae ?
-
 ?

Synonyms

Synonyms Comment Organism
undecaprenyl pyrophosphate synthase
-
 Streptococcus pneumoniae
UPPs
-
 Streptococcus pneumoniae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00063
-
 pH 7.3, temperature not specified in the publication, N-(4-benzoylphenyl)-4-hydroxy-2-oxo-5-phenethyl-2,5-dihydro-1H-pyrrole-3-carboxamide as substrate Streptococcus pneumoniae 5-benzyl-4-hydroxy-5-methyl-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid (4-cyclohexylphenyl)amide