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Literature summary for 2.5.1.29 extracted from

  • Lao, Y.M.; Jin, H.; Zhou, J.; Zhang, H.J.; Zhu, X.S.; Cai, Z.H.
    A Novel Hydrolytic Activity of Tri-Functional Geranylgeranyl Pyrophosphate Synthase in Haematococcus pluvialis (2018), Plant Cell Physiol., 59, 2536-2548 .
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.008
-
dimethylallyl diphosphate pH 7.2, 20°C Haematococcus lacustris
0.012
-
geranyl diphosphate pH 7.2, 20°C Haematococcus lacustris
0.019
-
(2E,6E)-farnesyl diphosphate pH 7.2, 20°C Haematococcus lacustris
0.039
-
isopentenyl diphosphate pH 7.2, 20°C Haematococcus lacustris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate Haematococcus lacustris the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate diphosphate + geranylgeranyl diphosphate
-
?
dimethylallyl diphosphate + isopentenyl diphosphate Haematococcus lacustris the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate diphosphate + geranyl diphosphate
-
?
geranyl diphosphate + isopentenyl diphosphate Haematococcus lacustris reaction of EC 2.5.1.10, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate diphosphate + (2E,6E)-farnesyl diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Haematococcus lacustris A0A0K0TQ44 i..e. Haematococcus pluvialis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate Haematococcus lacustris diphosphate + geranylgeranyl diphosphate
-
?
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate Haematococcus lacustris diphosphate + geranylgeranyl diphosphate
-
?
dimethylallyl diphosphate + isopentenyl diphosphate the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate Haematococcus lacustris diphosphate + geranyl diphosphate
-
?
dimethylallyl diphosphate + isopentenyl diphosphate reaction of EC 2.5.1.1, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate Haematococcus lacustris diphosphate + geranyl diphosphate
-
?
geranyl diphosphate + isopentenyl diphosphate reaction of EC 2.5.1.10, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate Haematococcus lacustris diphosphate + (2E,6E)-farnesyl diphosphate
-
?
geranyl diphosphate + isopentenyl diphosphate reaction of EC 2.5.1.10, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate Haematococcus lacustris diphosphate + (2E,6E)-farnesyl diphosphate
-
?

Synonyms

Synonyms Comment Organism
HpGGPPS
-
Haematococcus lacustris

General Information

General Information Comment Organism
metabolism under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by geranylgeranyl pyrophosphate synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate. Transcription of geranylgeranyl pyrophosphate synthase genes, morphological transformation, and carotenoid biosynthesis are differentially induced by environmental stresses, while the products of the enzyme are low in vivo, implying that most of prenyl pyrophosphate flux is shunted into carotenoid biosynthesis Haematococcus lacustris
physiological function under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by geranylgeranyl pyrophosphate synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate. Transcription of geranylgeranyl pyrophosphate synthase genes, morphological transformation, and carotenoid biosynthesis are differentially induced by environmental stresses, while the products of the enzyme are low in vivo, implying that most of prenyl pyrophosphate flux is shunted into carotenoid biosynthesis Haematococcus lacustris