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Literature summary for 2.5.1.29 extracted from

  • Han, S.; Li, X.; Xia, Y.; Yu, Z.; Cai, N.; Malwal, S.R.; Han, X.; Oldfield, E.; Zhang, Y.
    Farnesyl pyrophosphate synthase as a target for drug development discovery of natural-product-derived inhibitors and their activity in pancreatic cancer cells (2019), J. Med. Chem., 62, 10867-10896 .
    View publication on PubMed
Search for more literature for 2.5.1.29

Inhibitors

Inhibitors Comment Organism Structure
(4aR,10aS)-4a-[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-2,3,4,4a,10,10a-hexahydrophenanthren-9(1H)-one
-
 Homo sapiens
(4aR,10aS)-4a-[5-[(1R)-1-aminoethyl]-1,3,4-oxadiazol-2-yl]-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-2,3,4,4a,10,10a-hexahydrophenanthren-9(1H)-one
-
 Homo sapiens
(4bR,8aS)-4b-(5-acetyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione
-
 Homo sapiens
(4bR,8aS)-4b-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione
-
 Homo sapiens
(4bR,8aS)-4b-(5-[(1S)-1-[(hydroxymethyl)amino]ethyl]-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol
-
 Homo sapiens
12-hydroxy-11,20-epoxyabieta-8(14),9(11),12-trien-20-one
-
 Homo sapiens
2-[11,12-dihydroxy-20-oxoabieta-8(14),9(11),12-trien-20-yl]hydrazine-1-carboxamide
-
 Homo sapiens
6,20-epoxyabieta-8,13-diene-7,11,12,20-tetrone
-
 Homo sapiens
7,20-epoxyabieta-8,13-diene-11,12-dione
-
 Homo sapiens
methyl 11,12-dihydroxy-7-(phenylsulfanyl)abieta-8(14),9(11),12-trien-20-oate
-
 Homo sapiens
methyl 11,12-dihydroxy-7-methoxyabieta-8(14),9(11),12-trien-20-oate
-
 Homo sapiens
methyl 11,12-dihydroxy-7-oxoabieta-8(14),9(11),12-trien-20-oate
-
 Homo sapiens
methyl 11,12-dihydroxyabieta-8(14),9(11),12-trien-20-oate
-
 Homo sapiens
methyl 7-[(2-hydroxyethyl)sulfanyl]-11,12-dioxoabieta-8,13-dien-20-oate
-
 Homo sapiens
N-acetyl-S-((4aR,10aS)-5,6-dihydroxy-7-isopropyl-4a-(methoxycarbonyl)-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-9-yl)-L-cysteine
-
 Homo sapiens
N-benzyl-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-amide
-
 Homo sapiens
N-cycloheptyl-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-amide
-
 Homo sapiens
tert-butyl [(1S)-1-[5-[(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate Homo sapiens
-
 diphosphate + geranylgeranyl diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O95749
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic cancer cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
-
 Homo sapiens diphosphate + geranylgeranyl diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
geranylgeranyl pyrophosphate synthase
-
 Homo sapiens
HsGGPPS
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
23
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0055
-
 pH 7.5, 23°C Homo sapiens methyl 11,12-dihydroxy-7-(phenylsulfanyl)abieta-8(14),9(11),12-trien-20-oate
0.0109
-
 pH 7.5, 23°C Homo sapiens (4bR,8aS)-4b-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione
0.0123
-
 pH 7.5, 23°C Homo sapiens (4bR,8aS)-4b-(5-acetyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione
0.0147
-
 pH 7.5, 23°C Homo sapiens 12-hydroxy-11,20-epoxyabieta-8(14),9(11),12-trien-20-one
0.0152
-
 pH 7.5, 23°C Homo sapiens methyl 11,12-dihydroxyabieta-8(14),9(11),12-trien-20-oate
0.0154
-
 pH 7.5, 23°C Homo sapiens N-acetyl-S-((4aR,10aS)-5,6-dihydroxy-7-isopropyl-4a-(methoxycarbonyl)-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-9-yl)-L-cysteine
0.0169
-
 pH 7.5, 23°C Homo sapiens 7,20-epoxyabieta-8,13-diene-11,12-dione
0.0232
-
 pH 7.5, 23°C Homo sapiens 6,20-epoxyabieta-8,13-diene-7,11,12,20-tetrone
0.0347
-
 pH 7.5, 23°C Homo sapiens N-cycloheptyl-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-amide
0.0354
-
 pH 7.5, 23°C Homo sapiens methyl 11,12-dihydroxy-7-methoxyabieta-8(14),9(11),12-trien-20-oate
0.0375
-
 pH 7.5, 23°C Homo sapiens tert-butyl [(1S)-1-[5-[(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate
0.0378
-
 pH 7.5, 23°C Homo sapiens N-benzyl-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-amide
0.0379
-
 pH 7.5, 23°C Homo sapiens 2-[11,12-dihydroxy-20-oxoabieta-8(14),9(11),12-trien-20-yl]hydrazine-1-carboxamide
0.04
-
 pH 7.5, 23°C Homo sapiens (4aR,10aS)-4a-[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-2,3,4,4a,10,10a-hexahydrophenanthren-9(1H)-one
0.0432
-
 pH 7.5, 23°C Homo sapiens (4bR,8aS)-4b-(5-[(1S)-1-[(hydroxymethyl)amino]ethyl]-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol
0.0436
-
 pH 7.5, 23°C Homo sapiens methyl 11,12-dihydroxy-7-oxoabieta-8(14),9(11),12-trien-20-oate
0.0459
-
 pH 7.5, 23°C Homo sapiens methyl 7-[(2-hydroxyethyl)sulfanyl]-11,12-dioxoabieta-8,13-dien-20-oate
0.0494
-
 pH 7.5, 23°C Homo sapiens (4aR,10aS)-4a-[5-[(1R)-1-aminoethyl]-1,3,4-oxadiazol-2-yl]-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-2,3,4,4a,10,10a-hexahydrophenanthren-9(1H)-one

General Information

General Information Comment Organism
drug target the enzyme is a target for treating bone resorption diseases and some cancers Homo sapiens