Inhibitors | Comment | Organism | Structure |
---|---|---|---|
digeranyl bisphosphonate | decreased intracellular GGPP levels in MC3T3-E1 pre-osteoblasts leading to impaired Rap1a geranylgeranylation. DGBP inhibits matrix mineralization in the MC3T3-E1 preosteoblasts | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate | Mus musculus | - |
diphosphate + geranylgeranyl diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MC3T3-E1 cell | pre-osteoblast line | Mus musculus | - |
osteoblast | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate | - |
Mus musculus | diphosphate + geranylgeranyl diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
geranylgeranyl pyrophosphate synthase | - |
Mus musculus |
GGPP synthase | - |
Mus musculus |
GGPPS | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | depletion of geranylgeranyl diphosphate by inhibitor statins leads to accumulation of farnesyl diphosphate, which activates nuclear hormone receptors stimulating osteoblast differentiation and bone formation. Statins directly inhibit HMG-CoA reductase, the first step of the isoprenoid biosynthesis pathway | Mus musculus |
physiological function | the enzyme is required for synthesis of geranylgeranyl diphosphate which is required for e.g. Rap1a geranylgeranylation | Mus musculus |