Cloned (Comment) | Organism |
---|---|
- |
Sulfolobus acidocaldarius |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
36873 | - |
x * 36873, calculated from sequence | Sulfolobus acidocaldarius |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate | Sulfolobus acidocaldarius | biosynthesis of geranylgeranyl diphosphate, a precursor for the ether-linked lipids | diphosphate + geranylgeranyl diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate | Sulfolobus acidocaldarius DSM 639 | biosynthesis of geranylgeranyl diphosphate, a precursor for the ether-linked lipids | diphosphate + geranylgeranyl diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sulfolobus acidocaldarius | P39464 | - |
- |
Sulfolobus acidocaldarius DSM 639 | P39464 | - |
- |
Purification (Comment) | Organism |
---|---|
partial | Sulfolobus acidocaldarius |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0087 | - |
pH and temperature not specified in the publication | Sulfolobus acidocaldarius |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate | biosynthesis of geranylgeranyl diphosphate, a precursor for the ether-linked lipids | Sulfolobus acidocaldarius | diphosphate + geranylgeranyl diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate | (2Z,6E)-farnesyl diphosphate is not a substrate. Dimethylallyl diphosphate, geranyl diphosphate, and (2E,6E)-farnesyl diphosphate are good substrates, with maximal activity for dimethylallyl diphosphate | Sulfolobus acidocaldarius | diphosphate + geranylgeranyl diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate | dimethylallyl diphosphate, geranyl diphosphate, and (2E,6E)-farnesyl diphosphate are, in decreasing order of activity, acceptable as allylic substrates to produce geranylgeranyl diphosphate. When dimethylallyl diphosphate or geranyl diphosphate are the allylic substrates, a significant amount of mixture of the products is shorter than geranylgeranyl diphosphate. (2Z,6E)-farnesyl diphosphate is not a substrate | Sulfolobus acidocaldarius | diphosphate + geranylgeranyl diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate | biosynthesis of geranylgeranyl diphosphate, a precursor for the ether-linked lipids | Sulfolobus acidocaldarius DSM 639 | diphosphate + geranylgeranyl diphosphate | - |
? | |
dimethylallyl diphosphate + 3 isopentenyl diphosphate | dimethylallyl diphosphate, geranyl diphosphate, and (2E,6E)-farnesyl diphosphate are good substrates, with maximal activity for dimethylallyl diphosphate | Sulfolobus acidocaldarius | geranylgeranyl diphosphate + 3 diphosphate | - |
? | |
dimethylallyl diphosphate + 3 isopentenyl diphosphate | dimethylallyl diphosphate, geranyl diphosphate, and (2E,6E)-farnesyl diphosphate are, in decreasing order of activity, acceptable as allylic substrates to produce geranylgeranyl diphosphate. When dimethylallyl diphosphate or geranyl diphosphate are the allylic substrates, a significant amount of mixture of the products is shorter than geranylgeranyl diphosphate. (2Z,6E)-farnesyl diphosphate is not a substrate | Sulfolobus acidocaldarius | geranylgeranyl diphosphate + 3 diphosphate | - |
? | |
dimethylallyl diphosphate + 3 isopentenyl diphosphate | dimethylallyl diphosphate, geranyl diphosphate, and (2E,6E)-farnesyl diphosphate are good substrates, with maximal activity for dimethylallyl diphosphate | Sulfolobus acidocaldarius DSM 639 | geranylgeranyl diphosphate + 3 diphosphate | - |
? | |
dimethylallyl diphosphate + 3 isopentenyl diphosphate | dimethylallyl diphosphate, geranyl diphosphate, and (2E,6E)-farnesyl diphosphate are, in decreasing order of activity, acceptable as allylic substrates to produce geranylgeranyl diphosphate. When dimethylallyl diphosphate or geranyl diphosphate are the allylic substrates, a significant amount of mixture of the products is shorter than geranylgeranyl diphosphate. (2Z,6E)-farnesyl diphosphate is not a substrate | Sulfolobus acidocaldarius DSM 639 | geranylgeranyl diphosphate + 3 diphosphate | - |
? | |
geranyl diphosphate + 2 isopentenyl diphosphate | dimethylallyl diphosphate, geranyl diphosphate, and (2E,6E)-farnesyl diphosphate are good substrates, with maximal activity for dimethylallyl diphosphate | Sulfolobus acidocaldarius | geranylgeranyl diphosphate + 2 diphosphate | - |
? | |
geranyl diphosphate + 2 isopentenyl diphosphate | dimethylallyl diphosphate, geranyl diphosphate, and (2E,6E)-farnesyl diphosphate are, in decreasing order of activity, acceptable as allylic substrates to produce geranylgeranyl diphosphate. When dimethylallyl diphosphate or geranyl diphosphate are the allylic substrates, a significant amount of mixture of the products is shorter than geranylgeranyl diphosphate. (2Z,6E)-farnesyl diphosphate is not a substrate | Sulfolobus acidocaldarius | geranylgeranyl diphosphate + 2 diphosphate | - |
? | |
geranyl diphosphate + 2 isopentenyl diphosphate | dimethylallyl diphosphate, geranyl diphosphate, and (2E,6E)-farnesyl diphosphate are good substrates, with maximal activity for dimethylallyl diphosphate | Sulfolobus acidocaldarius DSM 639 | geranylgeranyl diphosphate + 2 diphosphate | - |
? | |
geranyl diphosphate + 2 isopentenyl diphosphate | dimethylallyl diphosphate, geranyl diphosphate, and (2E,6E)-farnesyl diphosphate are, in decreasing order of activity, acceptable as allylic substrates to produce geranylgeranyl diphosphate. When dimethylallyl diphosphate or geranyl diphosphate are the allylic substrates, a significant amount of mixture of the products is shorter than geranylgeranyl diphosphate. (2Z,6E)-farnesyl diphosphate is not a substrate | Sulfolobus acidocaldarius DSM 639 | geranylgeranyl diphosphate + 2 diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 36873, calculated from sequence | Sulfolobus acidocaldarius |
Synonyms | Comment | Organism |
---|---|---|
GGPP synthase | - |
Sulfolobus acidocaldarius |
Saci_0092 | locus name | Sulfolobus acidocaldarius |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | 70 | 100 min, most of the activity remains | Sulfolobus acidocaldarius |
60 | 70 | 100 min, most of the activity for geranylgeranyl synthase remains even after heating at 60 to 70°C for 100 min | Sulfolobus acidocaldarius |
90 | - |
10 min, 90% loss of activity | Sulfolobus acidocaldarius |
90 | - |
10 min, 90% of the enzyme activity is lost | Sulfolobus acidocaldarius |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.8 | - |
- |
Sulfolobus acidocaldarius |
5.9 | - |
- |
Sulfolobus acidocaldarius |
General Information | Comment | Organism |
---|---|---|
physiological function | biosynthesis of geranylgeranyl diphosphate, a precursor for the ether-linked lipids | Sulfolobus acidocaldarius |