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Literature summary for 2.5.1.26 extracted from
- Alkyldihydroxyacetone-P synthase. Solubilization, partial purification, new assay method, and evidence for a ping-pong mechanism (1982), J. Biol. Chem., 257, 8835-8839.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Mus musculus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-acylglycerone 3-phosphate + long-chain alcohol | Mus musculus | forms the ether bond found in alkyl and alk-1-enyl glycerolipids | alkylglycerone 3-phosphate + long-chain acid anion + H+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Mus musculus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| long-chain acylglycerone 3-phosphate + long-chain alcohol = long-chain alkylglycerone 3-phosphate + long-chain carboxylate | ping-pong mechanism | Mus musculus | |
| long-chain acylglycerone 3-phosphate + long-chain alcohol = long-chain alkylglycerone 3-phosphate + long-chain carboxylate | enzyme also catalyzes the following reactions: 1. acyl exchange reaction in which palmitic acid is incorporated into palmitoyldihydroxyacetone phosphate, 2. alkyl exchange reaction in which hexadecanol is incorporated into hexadecyldihydroxyacetone phosphate | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Ehrlich ascites carcinoma cell | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0208 | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-acylglycerone 3-phosphate + long-chain alcohol | 1-acylglycerone 3-phosphate is acyldihydroxyacetone phosphate, the ester-linked fatty acid of the substrate is cleaved and replaced by a long-chain alcohol in the ether | Mus musculus | alkylglycerone 3-phosphate + long-chain acid anion + H+ | - |
? | |
| 1-acylglycerone 3-phosphate + long-chain alcohol | forms the ether bond found in alkyl and alk-1-enyl glycerolipids | Mus musculus | alkylglycerone 3-phosphate + long-chain acid anion + H+ | - |
? | |
| additional information | alkyldihydroxyacetone phosphate synthase also catalyzes the following reactions: 1. acyl exchange reaction in which palmitic acid is incorporated into palmitoyldihydroxyacetone phosphate, 2. alkyl exchange reaction in which hexadecanol is incorporated into hexadecyldihydroxyacetone phosphate | Mus musculus | additional information | - |
? | |
| palmitoyldihydroxyacetone phosphate + hexadecanol | - |
Mus musculus | 1-O-hexadecyldihydroxyacetone phosphate + palmitate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Mus musculus |
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Release 2023.1 (January 2023)
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