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Literature summary for 2.5.1.22 extracted from

  • Ikeguchi, Y.; Wang, X.; McCloskey, D.E.; Coleman, C.S.; Nelson, P.; Hu, G.; Shantz, L.M.; Pegg, A.E.
    Characterization of transgenic mice with widespread overexpression of spermine synthase (2004), Biochem. J., 381, 701-707.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.22

Cloned(Commentary)

Cloned (Comment) Organism
enzyme overexpression in transgenic mice under control of a composite CMV-IE enhancer-chicken beta-actin promotor, 4 separate founder CAG/SpmS mice are analysed: enzyme expression in all tissues, mostly highly increased compared to the wild-type mice, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enzyme overexpression in transgenic mice under control of a composite CMV-IE enhancer-chicken beta-actin promotor causes no deleterious effects, the mice show normal growth, fertility, and behaviour, the content of S-adenosylmethionine in transgenic mice is important for viability, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens levels of spermidine and spermine are not only regulated by activity of spermidine synthase and spermine synthase, but also by other factors, e.g. the level of aminopropyl donor substrate, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
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dermis
-
 Homo sapiens
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epidermis
-
 Homo sapiens
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heart
-
 Homo sapiens
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kidney
-
 Homo sapiens
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liver
-
 Homo sapiens
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lung
-
 Homo sapiens
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muscle
-
 Homo sapiens
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testis
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 activity in vivo in wild-type and transgenic CAG/SpmS mice, polyamine contents, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information levels of spermidine and spermine are not only regulated by activity of spermidine synthase and spermine synthase, but also by other factors, e.g. the level of aminopropyl donor substrate, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
SpmS
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 Homo sapiens