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Literature summary for 2.5.1.21 extracted from

  • Ginzberg, I.; Thippeswamy, M.; Fogelman, E.; Demirel, U.; Mweetwa, A.M.; Tokuhisa, J.; Veilleux, R.E.
    Induction of potato steroidal glycoalkaloid biosynthetic pathway by overexpression of cDNA encoding primary metabolism HMG-CoA reductase and squalene synthase (2012), Planta, 235, 1341-1353.
    View publication on PubMed
Search for more literature for 2.5.1.21

Cloned(Commentary)

Cloned (Comment) Organism
clone 8380-1, gene PSS1, DNA and amino acid sequence determination and analysis, overexpression in Solanum tuberosum plants, only four of 12 SQS-transgenics have greater steroidal glycoalkaloid levels than control, quantitative real-time PCR expression analysis Solanum tuberosum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 (2E,6E)-farnesyl diphosphate + NADPH + H+ Solanum tuberosum overall reaction squalene + 2 diphosphate + NADP+
-
 ?
2 (2E,6E)-farnesyl diphosphate + NADPH + H+ Solanum tuberosum Desiree overall reaction squalene + 2 diphosphate + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Solanum tuberosum Q9XJ31 gene PSS1; clone 8380-1
-
Solanum tuberosum Desiree Q9XJ31 gene PSS1; clone 8380-1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 (2E,6E)-farnesyl diphosphate + NADPH + H+ overall reaction Solanum tuberosum squalene + 2 diphosphate + NADP+
-
 ?
2 (2E,6E)-farnesyl diphosphate + NADPH + H+ overall reaction Solanum tuberosum Desiree squalene + 2 diphosphate + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
SQS1
-
 Solanum tuberosum
squalene synthase 1
-
 Solanum tuberosum

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Solanum tuberosum