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Literature summary for 2.5.1.21 extracted from

  • Busquets, A.; Keim, V.; Closa, M.; del Arco, A.; Boronat, A.; Arro, M.; Ferrer, A.
    Arabidopsis thaliana contains a single gene encoding squalene synthase (2008), Plant Mol. Biol., 67, 25-36.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression as green fluorescent protein-tagged version in onion Arabidopsis thaliana
expression in Escherichia coli Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information expression as fusion protein after replacement of the 69 C-terminal residues of SQS2 by the111 C-terminal residues of the Schizosaccharomyces pombe. Like wild-type, the fusion protein has no catalytic activity Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum localization depends on the protein's N-terminal hydrophobic transmembrane domain Arabidopsis thaliana 5783
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Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana O23118 isoform Sqs2, lacking enzymatic activity due to the presence of an unusual Ser replacing the highly conserved Phe at position 287
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Arabidopsis thaliana P53799 isoform Sqs1. Sqs1 is the only functional squalene synthase in Arabidopsis thaliana. Isoform Sqs2 has no squalene synthase activity
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Source Tissue

Source Tissue Comment Organism Textmining
cotyledon petiole of cotyledon Arabidopsis thaliana
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hypocotyl of seedling Arabidopsis thaliana
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leaf vascular tissue of leaf Arabidopsis thaliana
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additional information isoform Sqs1 is widely expressed in all tissues throughout plant development Arabidopsis thaliana
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