Literature summary for 2.5.1.21 extracted from

Bedi, M.; Niesen, M.; Lopez, D.
Inhibition of squalene synthase upregulates PCSK9 expression in rat liver (2008), Arch. Biochem. Biophys., 470, 116-119.

Search for more literature for 2.5.1.21

Inhibitors

Inhibitors	Comment	Organism	Structure
zaragozic acid A	inhibition of squalene synthase. Administration also significantly increases the rate of degradation of hepatic low density lipoprotein receptor protein, and increases proprotein convertase subtilisin/kexin type 9 mRNA and protein levels in concert with an increase in hepatic low density lipoprotein receptor mRNA levels, low density lipoprotein turnover, and decreases in serum cholesterol levels	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)