Literature summary for 2.5.1.21 extracted from

Pandit, J.; Danley, D.E.; Schulte, G.K.; Mazzalupo, S.; Pauly, T.A.; Hayward, C.M.; Hamanaka, E.S.; Thompson, J.F.; Harwood, H.J., Jr.
Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis (2000), J. Biol. Chem., 275, 30610-30617.

Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with different inhibitors	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	P37268	recombinant enzyme	-

Reaction	Comment	Organism	Reaction ID
2 (2E,6E)-farnesyl diphosphate + NAD(P)H + H+ = squalene + 2 diphosphate + NAD(P)+	mechanism	Homo sapiens	a

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Release 2023.1 (January 2023)