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Literature summary for 2.5.1.21 extracted from

  • Agnew, W.S.; Popjak, G.
    Squalene synthetase. Solubilization from yeast microsomes of a phospholipid-requiring enzyme (1978), J. Biol. Chem., 253, 4574-4583.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information absolute requirement for phospholipid Saccharomyces cerevisiae

General Stability

General Stability Organism
NADPH has no effect on stability Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
deoxycholate
-
Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Saccharomyces cerevisiae
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54500
-
gel filtration, sucrose density gradient sedimentation Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesyl diphosphate + NAD(P)H
-
Saccharomyces cerevisiae squalene + diphosphate + NAD(P)+
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
25
-
in presence of deoxycholate, 5 min, 50% loss of activity Saccharomyces cerevisiae
41
-
without deoxycholate, 5 min, 50% loss of activity Saccharomyces cerevisiae