Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NADPH | stimulates | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | peroxisomal squalene synthase is inhibited by sonication, microsomal enzyme not | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Rattus norvegicus | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.16 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
farnesyl diphosphate + farnesyl diphosphate | - |
Rattus norvegicus | diphosphate + presqualene diphosphate | - |
? | |
farnesyl diphosphate + NAD(P)H | - |
Rattus norvegicus | squalene + diphosphate + NAD(P)+ | - |
? | |
presqualene diphosphate + NAD(P)H | in presence of reducing pyridine nucleotide, preferably NADPH, squalene is formed, in absence of reducing cofactor the rate of the condensation reaction is lower and all of the product accumulates as presqualene diphosphate | Rattus norvegicus | squalene + NAD(P)+ + diphosphate | - |
? |