Cloned (Comment) | Organism |
---|---|
GSTP1-1 expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol | a coumaroflavan from Treculia africana, 26% total inhibition at 0.033 mM | Homo sapiens | |
(4S,6Z,10Z,11aS)-4-ethoxy-6-(hydroxymethyl)-3-methylidene-10-propoxy-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one | a sesquiterpene lactone from Dicoma anomala collected from Namibia, 75% total inhibition at 0.033 mM | Homo sapiens | |
1,7-dihydroxyanthracen-9(10H)-one | a xanthone from Mammea africana, 21% total inhibition at 0.033 mM | Homo sapiens | |
2-hydroxyanthracen-9(10H)-one | a xanthone Mammea from africana, 38% total inhibition at 0.033 mM | Homo sapiens | |
3-(3,4-dihydroxybenzoyl)-4-hydroxy-8-methyl-1,5,7-tris(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione | a benzophenone Garcinia smeathmannii, 41% total inhibition at 0.033 mM | Homo sapiens | |
3-ethyl-2-oxo-3,3a,7a,9b-tetrahydro-2H,4aH-1,4,5-trioxadicyclopenta[a,hi]indene-7-carboxylic acid | an iridoid from Plumeeria rubra, 51% total inhibition at 0.033 mM | Homo sapiens | |
4-[3-(5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)-3-hydroxybutoxy]-7H-furo[3,2-g]chromen-7-one | a furocoumarin from Dorstenia elliptica, 34% total inhibition at 0.033 mM | Homo sapiens | |
5,7-dihydroxy-6-(2-hydroxybutanoyl)-8-(3-methylbut-2-en-1-yl)-4-propyl-2H-chromen-2-one | a coumarin from Mammea africana, 33% total inhibition at 0.033 mM | Homo sapiens | |
5,8-dihydroxy-1-(hydroxymethyl)naphtho[2,3-c]furan-4,9-dione | an isofuranonaphthoquinone from Bulbine frutescens, the mode of inhibition is mixed, partial (G site) and noncompetitive (H site), 68% total inhibition at 0.033 mM | Homo sapiens | |
6-butanoyl-5,7-dihydroxy-4-phenyl-2H-chromen-2-one | a coumarin from Mammea africana, 23% total inhibition at 0.033 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant GSTP1-1 from Escherichia coli | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-chloro-2,4-dinitrobenzene + glutathione | - |
Homo sapiens | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
monochlorobimane + glutathione | - |
Homo sapiens | bimane-glutathione + HCl | - |
? | |
additional information | monochlorobimane and 1-chloro-2,4-dinitrobenzene are used to determine GST activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione transferase P1-1 | - |
Homo sapiens |
GST | - |
Homo sapiens |
GSTP1-1 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00021 | - |
5,8-dihydroxy-1-(hydroxymethyl)naphtho[2,3-c]furan-4,9-dione | inhibition H site, pH and temperature not specified in the publication | Homo sapiens | |
0.0088 | - |
5,8-dihydroxy-1-(hydroxymethyl)naphtho[2,3-c]furan-4,9-dione | inhibition G site, pH and temperature not specified in the publication | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0068 | - |
pH and temperature not specified in the publication | Homo sapiens | 5,8-dihydroxy-1-(hydroxymethyl)naphtho[2,3-c]furan-4,9-dione |