Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.18 extracted from

  • Imaizumi, N.; Aniya, Y.
    The role of a membrane-bound glutathione transferase in the peroxynitrite-induced mitochondrial permeability transition pore: formation of a disulfide-linked protein complex (2011), Arch. Biochem. Biophys., 516, 160-172.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
Rattus norvegicus
bongkrekic acid
-
Rattus norvegicus
Cibacron blue
-
Rattus norvegicus
dithiothreitol
-
Rattus norvegicus
additional information no inhibition by EGTA and deferoxamine Rattus norvegicus
peroxynitrite
-
Rattus norvegicus
S-hexylglutathione
-
Rattus norvegicus
Tannic acid
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane bound Rattus norvegicus 31966
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Sprague-Dawley
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially by mitochondrion isolation Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
mtMGST1
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Rattus norvegicus

General Information

General Information Comment Organism
physiological function role of mtMGST1 in the oxidant peroxynitrite-induced mitochondrial permeability transition, MPT, pore opening, peroxynitrite induces the swelling of mitoplasts (inner membranes including the matrix) as well as of the mitochondria. mtMGST1, ADP (an adenine nucleotide translocator),and cyclosporin A function as a MPT pore in peroxynitrite-induced swelling, in which the Ca2+ released by peroxynitrite might play an important role in the complex formation Rattus norvegicus