Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Rattus norvegicus | |
bongkrekic acid | - |
Rattus norvegicus | |
Cibacron blue | - |
Rattus norvegicus | |
dithiothreitol | - |
Rattus norvegicus | |
additional information | no inhibition by EGTA and deferoxamine | Rattus norvegicus | |
peroxynitrite | - |
Rattus norvegicus | |
S-hexylglutathione | - |
Rattus norvegicus | |
Tannic acid | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial membrane | bound | Rattus norvegicus | 31966 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Sprague-Dawley | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme partially by mitochondrion isolation | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
mtMGST1 | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | role of mtMGST1 in the oxidant peroxynitrite-induced mitochondrial permeability transition, MPT, pore opening, peroxynitrite induces the swelling of mitoplasts (inner membranes including the matrix) as well as of the mitochondria. mtMGST1, ADP (an adenine nucleotide translocator),and cyclosporin A function as a MPT pore in peroxynitrite-induced swelling, in which the Ca2+ released by peroxynitrite might play an important role in the complex formation | Rattus norvegicus |