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Literature summary for 2.5.1.18 extracted from

  • Liebau, E.; Eckelt, V.H.O.; Wildenburg, G.; Teesdale-Spittle, P.; Brophy, P.M.; Walter, R.D.; Henkle-Duhrsen, K.
    Structural and functional analysis of a glutathione S-transferase from Ascaris sum (1997), Biochem. J., 324, 659-666.
No PubMed abstract available
Search for more literature for 2.5.1.18

Cloned(Commentary)

Cloned (Comment) Organism
-
 Ascaris suum

Inhibitors

Inhibitors Comment Organism Structure
2,3,4,5-tetrahydroxy-6H-benzo[7]annulen-6-one 50% inhibition at 0.0052 mM Ascaris suum
albendazole 50% inhibition at 0.52 mM Ascaris suum
alizarin 50% inhibition at 0.0042 mM Ascaris suum
bilirubin 50% inhibition at 0.009 mM Ascaris suum
bithionol 50% inhibition at 0.0077 mM Ascaris suum
bromosulfophthalein 50% inhibition at 0.001 mM Ascaris suum
chalcone 50% inhibition at 0.045 mM Ascaris suum
Cibacron blue 50% inhibition at 0.00009 mM Ascaris suum
ellagic acid 50% inhibition at 0.0006 mM Ascaris suum
Hexachlorophene 50% inhibition at 0.00034 mM Ascaris suum
lithocholate 50% inhibition at 0.1 mM Ascaris suum
protoporphyrin IX 50% inhibition at 0.03 mM Ascaris suum
quercetin 50% inhibition at 0.0006 mM Ascaris suum
Triphenyltin chloride 50% inhibition at 0.0003 mM Ascaris suum

Organism

Organism UniProt Comment Textmining
Ascaris suum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein after expression in E. coli Ascaris suum

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Ascaris suum
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.26
-
 with ethacrynic acid as substrate Ascaris suum
0.312
-
 with cumene hydroperoxide as substrate Ascaris suum
38.2
-
 with 1,2-dichloro-4-nitrobenzene as substrate Ascaris suum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + 1-chloro-2,4-dinitrobenzene
-
 Ascaris suum S-2,4-dinitrophenylglutathione + HCl
-
 ?
glutathione + cumene hydroperoxide
-
 Ascaris suum ?
-
 ?
glutathione + ethacrynic acid
-
 Ascaris suum ?
-
 ?
additional information enzyme has also activity towards reactive carbonyls Ascaris suum ?
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Ascaris suum