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Literature summary for 2.5.1.18 extracted from

  • Jakoby, W.B.; Keen, J.H.
    A triple-threat in detoxification: the glutathione S-transferases (1977), Trends Biochem. Sci., 2, 229-231.
No PubMed abstract available
Search for more literature for 2.5.1.18

General Stability

General Stability Organism
guanidine hydrochloride, 6 M, denaturation Homo sapiens
guanidine hydrochloride, 6 M, denaturation Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
-
 Homo sapiens
45000
-
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RX + glutathione Homo sapiens participates in detoxification HX + R-S-glutathione
-
 ?
RX + glutathione Rattus norvegicus participates in detoxification HX + R-S-glutathione
-
 ?
RX + glutathione Homo sapiens first step in mercapturic acid synthesis HX + R-S-glutathione
-
 ?
RX + glutathione Rattus norvegicus first step in mercapturic acid synthesis HX + R-S-glutathione
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Pisum sativum
-
 pea
-
Rattus norvegicus
-
-
-
Zea mays
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens
-
 Rattus norvegicus
-
 Zea mays

Reaction

Reaction Comment Organism Reaction ID
RX + glutathione = HX + R-S-glutathione mechanism Homo sapiens
a
RX + glutathione = HX + R-S-glutathione mechanism Rattus norvegicus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + 1,2-dichloro-4-nitrobenzene
-
 Homo sapiens ?
-
 ?
glutathione + 1,2-dichloro-4-nitrobenzene
-
 Rattus norvegicus ?
-
 ?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
-
 Rattus norvegicus ?
-
 ?
glutathione + 1-chloro-2,4-dinitrobenzene
-
 Homo sapiens S-2,4-dinitrophenylglutathione + HCl
-
 ?
glutathione + 1-chloro-2,4-dinitrobenzene
-
 Rattus norvegicus S-2,4-dinitrophenylglutathione + HCl
-
 ?
glutathione + 1-chloro-2,4-dinitrobenzene
-
 Pisum sativum S-2,4-dinitrophenylglutathione + HCl
-
 ?
glutathione + 1-chloro-2,4-dinitrobenzene
-
 Zea mays S-2,4-dinitrophenylglutathione + HCl
-
 ?
glutathione + ethacrynic acid
-
 Homo sapiens ?
-
 ?
glutathione + ethacrynic acid
-
 Rattus norvegicus ?
-
 ?
glutathione + iodomethane
-
 Homo sapiens ?
-
 ?
glutathione + iodomethane
-
 Rattus norvegicus ?
-
 ?
additional information catalyzes the reaction of glutathione with a large number of compounds bearing an electrophilic carbon to form the corresponding thioether Homo sapiens ?
-
 ?
additional information catalyzes the reaction of glutathione with a large number of compounds bearing an electrophilic carbon to form the corresponding thioether Rattus norvegicus ?
-
 ?
additional information isomerization of DELTA5- to DELTA4- unsaturated 3-keto steroids Homo sapiens ?
-
 ?
additional information isomerization of DELTA5- to DELTA4- unsaturated 3-keto steroids Rattus norvegicus ?
-
 ?
RSSR + glutathione
-
 Homo sapiens glutathione-SSR + R-SH
-
 ?
RSSR + glutathione
-
 Rattus norvegicus glutathione-SSR + R-SH
-
 ?
RX + glutathione participates in detoxification Homo sapiens HX + R-S-glutathione
-
 ?
RX + glutathione participates in detoxification Rattus norvegicus HX + R-S-glutathione
-
 ?
RX + glutathione first step in mercapturic acid synthesis Homo sapiens HX + R-S-glutathione
-
 ?
RX + glutathione first step in mercapturic acid synthesis Rattus norvegicus HX + R-S-glutathione
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Homo sapiens
dimer
-
 Rattus norvegicus
dimer
-
 Pisum sativum
dimer
-
 Zea mays