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Literature summary for 2.5.1.18 extracted from
- Purification and characterization of three distinct glutathione transferases from mouse liver (1986), Biochemistry, 25, 4119-4125.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| N-ethylmaleimide | - |
Mus musculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bromosulfophthalein | - |
Mus musculus | |
| Cibacron blue | - |
Mus musculus | |
| Hematin | - |
Mus musculus | |
| additional information | difference in sensitivity to inhibition of enzyme MI, MII and MIII | Mus musculus | |
| S-(4-Bromobenzyl)glutathione | - |
Mus musculus | |
| S-hexylglutathione | - |
Mus musculus | |
| sulfophthalein | - |
Mus musculus | |
| Tributyltin acetate | - |
Mus musculus | |
| Triethyltin bromide | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 23000 | - |
2 * 23000, enzyme MII, SDS-PAGE | Mus musculus |
| 25000 | - |
2 * 25000, enzyme MI, SDS-PAGE | Mus musculus |
| 26500 | - |
2 * 26500, enzyme MIII, SDS-PAGE | Mus musculus |
| 45000 | - |
gel filtration | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
3 forms, products of different genes: MI, MII, MIII | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 148 | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + 1,2-dichloro-4-nitrobenzene | enzyme MIII | Mus musculus | ? | - |
? | |
| glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane | - |
Mus musculus | ? | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Mus musculus | S-2,4-dinitrophenylglutathione + HCl | - |
? | |
| glutathione + 4-hydroxydecenal | - |
Mus musculus | ? | - |
? | |
| glutathione + 4-hydroxynonenal | - |
Mus musculus | ? | - |
? | |
| glutathione + cumene hydroperoxide | isozyme MI | Mus musculus | ? | - |
? | |
| additional information | specificity | Mus musculus | ? | - |
? | |
| RX + glutathione | RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange | Mus musculus | HX + R-S-glutathione | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 23000, enzyme MII, SDS-PAGE | Mus musculus |
| dimer | 2 * 25000, enzyme MI, SDS-PAGE | Mus musculus |
| dimer | 2 * 26500, enzyme MIII, SDS-PAGE | Mus musculus |
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