Literature summary for 2.5.1.16 extracted from

Bitonti, A.J.; Kelly, S.E.; McCann, P.P.
Characterization of spermidine synthase from Trypanosoma brucei brucei (1984), Mol. Biochem. Parasitol., 13, 21-28.

Search for more literature for 2.5.1.16

Inhibitors

Inhibitors	Comment	Organism	Structure
Cyclohexylamine	in vitro, 50% inhibition at 0.015 mM, competitive with 1,4-diaminobutane	Trypanosoma brucei brucei
S-Adenosyl-1,8-diamino-3-thiooctane	potent, 50% inhibition at 0.025 mM	Trypanosoma brucei brucei

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
74000	-	gel filtration and sucrose density gradient centrifugation	Trypanosoma brucei brucei

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane	Trypanosoma brucei brucei	-	5'-methylthioadenosine + spermidine	-	?

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma brucei brucei	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane	-	Trypanosoma brucei brucei	5'-methylthioadenosine + spermidine	-	?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane	-	Trypanosoma brucei brucei	5'-methylthioadenosine + spermidine	-	?

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Release 2023.1 (January 2023)