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Literature summary for 2.5.1.154 extracted from

  • Buan, N.R.; Suh, S.J.; Escalante-Semerena, J.C.
    The eutT gene of Salmonella enterica encodes an oxygen-labile, metal-containing ATP corrinoid adenosyltransferase enzyme (2004), J. Bacteriol., 186, 5708-5714 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
bathophenanthroline complete loss of acitivty Salmonella enterica subsp. enterica serovar Typhimurium
O2 complete loss of activity upon exposure to air Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ATP + 2 cob(II)alamin + a reduced flavoprotein Salmonella enterica subsp. enterica serovar Typhimurium
-
2 diphosphate + 2 phosphate + 2 adenosylcob(III)alamin + an oxidized flavoprotein
-
?
2 ATP + 2 [corrinoid adenosyltransferase]-cob(I)alamin Salmonella enterica subsp. enterica serovar Typhimurium
-
2 diphosphate + 2 phosphate + 2 adenosylcob(III)alamin + 2 [corrinoid adenosyltransferase]
-
?
2 cob(II)alamin + 2 [corrinoid adenosyltransferase] Salmonella enterica subsp. enterica serovar Typhimurium
-
2 [corrinoid adenosyltransferase]-cob(II)alamin
-
?
a reduced flavoprotein + 2 [corrinoid adenosyltransferase]-cob(II)alamin Salmonella enterica subsp. enterica serovar Typhimurium
-
an oxidized flavoprotein + 2 [corrinoid adenosyltransferase]-cob(I)alamin
-
?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium Q9ZFV4
-
-

Oxidation Stability

Oxidation Stability Organism
complete loss of activity upon exposure to air Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + 2 cob(II)alamin + a reduced flavoprotein
-
Salmonella enterica subsp. enterica serovar Typhimurium 2 diphosphate + 2 phosphate + 2 adenosylcob(III)alamin + an oxidized flavoprotein
-
?
2 ATP + 2 [corrinoid adenosyltransferase]-cob(I)alamin
-
Salmonella enterica subsp. enterica serovar Typhimurium 2 diphosphate + 2 phosphate + 2 adenosylcob(III)alamin + 2 [corrinoid adenosyltransferase]
-
?
2 cob(II)alamin + 2 [corrinoid adenosyltransferase]
-
Salmonella enterica subsp. enterica serovar Typhimurium 2 [corrinoid adenosyltransferase]-cob(II)alamin
-
?
a reduced flavoprotein + 2 [corrinoid adenosyltransferase]-cob(II)alamin
-
Salmonella enterica subsp. enterica serovar Typhimurium an oxidized flavoprotein + 2 [corrinoid adenosyltransferase]-cob(I)alamin
-
?

Synonyms

Synonyms Comment Organism
EutT
-
Salmonella enterica subsp. enterica serovar Typhimurium

General Information

General Information Comment Organism
physiological function lack of corrinoid adenosyltransferase CobA, Ec 2.5.1.17, and EutT blocks ethanolamine utilization. EutT is necessary and sufficient for growth of an Salmonella typhimurium CobA EutT mutant strain on ethanolamine as a carbon and energy or nitrogen source. Cell extracts enriched for EutT protein contain strong, readily detectable ATP:co(I)rrinoid adenosyltransferase activity. The activity is only detected in extracts maintained under anoxic conditions Salmonella enterica subsp. enterica serovar Typhimurium