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Literature summary for 2.5.1.153 extracted from

  • Layre, E.; Lee, H.J.; Young, D.C.; Martinot, A.J.; Buter, J.; Minnaard, A.J.; Annand, J.W.; Fortune, S.M.; Snider, B.B.; Matsunaga, I.; Rubin, E.J.; Alber, T.; Moody, D.B.
    Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c (2014), Proc. Natl. Acad. Sci. USA, 111, 2978-2983 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.153

Application

Application Comment Organism
diagnostics the Mycobacterium tuberculosis-specific lipid 1-tuberculosinyladenosine is a target for diagnosing tuberculosis disease Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
vapor diffusion, and 2.2 A resolution, crystal structure reveals a cis-prenyl transferase fold with hydrophobic residues for isoprenoid binding and a second binding pocket suitable for the nucleoside substrate Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tuberculosinyl diphosphate + adenosine Mycobacterium tuberculosis the enzyme produces 1-tuberculosinyladenosine, an abundant amphiphile that is exported outside Mycobacterium tuberculosis 1-tuberculosinyladenosine + diphosphate
-
 ?
tuberculosinyl diphosphate + adenosine Mycobacterium tuberculosis ATCC 25618 the enzyme produces 1-tuberculosinyladenosine, an abundant amphiphile that is exported outside Mycobacterium tuberculosis 1-tuberculosinyladenosine + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WJ61
-
-
Mycobacterium tuberculosis ATCC 25618 P9WJ61
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tuberculosinyl diphosphate + adenosine the enzyme produces 1-tuberculosinyladenosine, an abundant amphiphile that is exported outside Mycobacterium tuberculosis Mycobacterium tuberculosis 1-tuberculosinyladenosine + diphosphate
-
 ?
tuberculosinyl diphosphate + adenosine
-
 Mycobacterium tuberculosis 1-tuberculosinyladenosine + diphosphate
-
 ?
tuberculosinyl diphosphate + adenosine the enzyme produces 1-tuberculosinyladenosine, an abundant amphiphile that is exported outside Mycobacterium tuberculosis Mycobacterium tuberculosis ATCC 25618 1-tuberculosinyladenosine + diphosphate
-
 ?
tuberculosinyl diphosphate + adenosine
-
 Mycobacterium tuberculosis ATCC 25618 1-tuberculosinyladenosine + diphosphate
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
Rv3378c
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
evolution adenosine tuberculosinyltransferase is known only in Mycobacterium tuberculosis. This intersection of nucleoside andterpene pathways likely arose late in the evolution of the Mycobacterium tuberculosis complex Mycobacterium tuberculosis
physiological function the extracellular export of the amphipathic molecule 1-tuberculosinyladenosine likely accounts for the known virulence-promoting effects of the Rv3378c enzyme Mycobacterium tuberculosis