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Literature summary for 2.5.1.153 extracted from

  • Hoshino, T.; Nakano, C.; Ootsuka, T.; Shinohara, Y.; Hara, T.
    Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis (2011), Org. Biomol. Chem., 9, 2156-2165.
    View publication on PubMed
Search for more literature for 2.5.1.153

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Mycobacterium tuberculosis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ essential for the enzymatic activities Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 tuberculosinyl diphosphate + 2 H2O
-
 Mycobacterium tuberculosis (13R)-isotuberculosinol + (13S)-isotuberculosinol + 2 diphosphate the product ratio of (13R)-isotuberculosinol and (13S)-isotuberculosinol is 1:3 ?
copalyl diphosphate + H2O
-
 Mycobacterium tuberculosis (+)-copalol + manool + 13-epi-manool + diphosphate 40% (+)-copalol, 12% manool and 15% 13-epi-manool ?
copalyl diphosphate + H2O
-
 Mycobacterium tuberculosis H37Rv (+)-copalol + manool + 13-epi-manool + diphosphate 40% (+)-copalol, 12% manool and 15% 13-epi-manool ?
ent-copalyl diphosphate + H2O
-
 Mycobacterium tuberculosis (-)-ent copalol + ent-13-epi-manool + ent-manool + diphosphate 22% (-)-ent copalol, 8% ent-13-epi-mancol, and 42% ent-manool ?
ent-copalyl diphosphate + H2O
-
 Mycobacterium tuberculosis H37Rv (-)-ent copalol + ent-13-epi-manool + ent-manool + diphosphate 22% (-)-ent copalol, 8% ent-13-epi-mancol, and 42% ent-manool ?
additional information no activity with terpentedienyl diphosphate, geranylgeranyl diphosphate, farnesyl diphosphate, and geranyl diphosphate Mycobacterium tuberculosis ?
-
 ?
additional information no activity with terpentedienyl diphosphate, geranylgeranyl diphosphate, farnesyl diphosphate, and geranyl diphosphate Mycobacterium tuberculosis H37Rv ?
-
 ?
syn-copalyl diphosphate + H2O
-
 Mycobacterium tuberculosis syn-copalol + (13R)-vitexifolin + (13S)-vitexifolin + diphosphate 16% syn-copalol, 3% (13R)-vitrxifolin and 59% (13S)-vitexifolin ?
syn-copalyl diphosphate + H2O
-
 Mycobacterium tuberculosis H37Rv syn-copalol + (13R)-vitexifolin + (13S)-vitexifolin + diphosphate 16% syn-copalol, 3% (13R)-vitrxifolin and 59% (13S)-vitexifolin ?
tuberculosinyl diphosphate + H2O
-
 Mycobacterium tuberculosis tuberculosinol + diphosphate
-
 ?
tuberculosinyl diphosphate + H2O
-
 Mycobacterium tuberculosis H37Rv tuberculosinol + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
Rv3378c protein
-
 Mycobacterium tuberculosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
45
-
-
 Mycobacterium tuberculosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Mycobacterium tuberculosis

pH Range

pH Minimum pH Maximum Comment Organism
5.5 9
-
 Mycobacterium tuberculosis