Literature summary for 2.5.1.15 extracted from

Lumb, V.; Das, M.K.; Mittra, P.; Ahmed, A.; Kumar, M.; Kaur, P.; Dash, A.P.; Singh, S.S.; Sharma, Y.D.
Emergence of an unusual sulfadoxine-pyrimethamine resistance pattern and a novel K540N mutation in dihydropteroate synthetase in Plasmodium falciparum isolates obtained from Car Nicobar Island, India, after the 2004 Tsunami (2009), J. Infect. Dis., 199, 1064-1073.

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Protein Variants

Protein Variants	Comment	Organism
K540N	parasites collected during October 2005 have mutations associated with a lower level of pyrimethamine resistance and a higher level of sulfadoxine resistance, as well as a novel K540N mutation in PfDHPS gene. The emergence of this parasite population coincides with the widespread use of an additional antifolate drug, trimethoprim-sulfamethoxazole, to treat other infections during January-March 2005	Plasmodium falciparum

Inhibitors

Inhibitors	Comment	Organism	Structure
7-amino-3-(1-carboxyethyl)-1-methyl-pyrimido (4,5-c)-pyridazine-4,5(1H,6H)-dione	-	Plasmodium falciparum
7-amino-3-(1-carboxyethyl)-1-methyl-pyrimido (4,5-c)-pyridazine-4,5(1H,6H)-dione	-	Pneumocystis jirovecii

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-
Pneumocystis jirovecii	-	-	-

Synonyms

Synonyms	Comment	Organism
DHPS	-	Pneumocystis jirovecii
dihydropteroate synthase	-	Plasmodium falciparum
dihydropteroate synthase	-	Pneumocystis jirovecii
PfDHPS	-	Plasmodium falciparum

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Release 2023.1 (January 2023)