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Literature summary for 2.5.1.15 extracted from
- Mutations in the Pneumocystis jirovecii DHPS gene confer cross-resistance to sulfa drugs (2005), Antimicrob. Agents Chemother., 49, 741-748.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Pneumocystis jirovecii |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| P519S | mutant with implicated sulfa drug resistance | Pneumocystis jirovecii |
| T517A | mutant with implicated sulfa drug resistance | Pneumocystis jirovecii |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dapsone | - |
Pneumocystis jirovecii |  |
| sulfacetamide | - |
Pneumocystis jirovecii | |
| sulfachlorpyridazine | - |
Pneumocystis jirovecii | |
| Sulfadiazine | - |
Pneumocystis jirovecii | |
| sulfadimethoxine | - |
Pneumocystis jirovecii | |
| sulfadoxine | - |
Pneumocystis jirovecii | |
| sulfamerazine | - |
Pneumocystis jirovecii | |
| sulfamethoxazole | - |
Pneumocystis jirovecii | |
| sulfamethoxypyridazine | - |
Pneumocystis jirovecii | |
| sulfamoxole | - |
Pneumocystis jirovecii | |
| sulfanilamide | - |
Pneumocystis jirovecii | |
| sulfapyridine | - |
Pneumocystis jirovecii | |
| sulfaquinoxaline | - |
Pneumocystis jirovecii | |
| sulfathiazole | - |
Pneumocystis jirovecii | |
| sulfisoxazole | - |
Pneumocystis jirovecii | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate | Pneumocystis jirovecii | - |
diphosphate + 7,8-dihydropteroate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pneumocystis jirovecii | Q9UUP4 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate | - |
Pneumocystis jirovecii | diphosphate + 7,8-dihydropteroate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 7,8-dihydropteroate synthase | - |
Pneumocystis jirovecii |
| DHPS | - |
Pneumocystis jirovecii |
| dihydropteroate synthetase | - |
Pneumocystis jirovecii |
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Release 2023.1 (January 2023)
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