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Literature summary for 2.5.1.15 extracted from

  • Djaman, J.A.; Mazabraud, A.; Basco, L.
    Sulfadoxine-pyrimethamine susceptibilities and analysis of the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum isolates from Cote d'Ivoire (2007), Ann. Trop. Med. Parasitol., 101, 103-112.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
A437G little association with between mutantion and sulfa drug resistance in patients Plasmodium falciparum
A613S little association with between mutantion and sulfa drug resistance in patients Plasmodium falciparum
additional information assessment of mutations in DHPS in West Africa Plasmodium falciparum
S436A little association with between mutantion and sulfa drug resistance in patients Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
pyrimethamine
-
Plasmodium falciparum
sulfadoxine-pyrimethamine
-
Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate Plasmodium falciparum
-
diphosphate + 7,8-dihydropteroate
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q27735 fragment of dihydropteroate synthase
-

Source Tissue

Source Tissue Comment Organism Textmining
bloodstream form
-
Plasmodium falciparum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
Plasmodium falciparum diphosphate + 7,8-dihydropteroate
-
?

Synonyms

Synonyms Comment Organism
7,8-dihydropteroate synthase
-
Plasmodium falciparum
DHPS
-
Plasmodium falciparum
dihydropteroate synthetase
-
Plasmodium falciparum