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Literature summary for 2.5.1.15 extracted from
- Characterization of a mutationally altered dihydropteroate synthase contributing to sulfathiazole resistance in Escherichia coli (1998), Microb. Drug Resist., 4, 91-97.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sulfathiazole | competitive to 4-aminobenzoate | Escherichia coli |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | values for recombinant enzymes | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Q-Sepharose column | Escherichia coli |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
specific activity in different strains | Escherichia coli |
| 0.0000483 | - |
crude extract of Escherichia coli MG1655 | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate | - |
Escherichia coli | diphosphate + 7,8-dihydropteroate | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | KI values of sulfathiazole for wild-type and mutant enzyme | Escherichia coli |
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