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Literature summary for 2.5.1.146 extracted from

  • Li, S.; Lowell, A.N.; Yu, F.; Raveh, A.; Newmister, S.A.; Bair, N.; Schaub, J.M.; Williams, R.M.; Sherman, D.H.
    Hapalindole/ambiguine biogenesis is mediated by a cope rearrangement, C-C bond-forming cascade (2015), J. Am. Chem. Soc., 137, 15366-15369 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Fischerella ambigua

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-[(E)-2-isocyanoethenyl]-1H-indole + geranyl diphosphate Fischerella ambigua preferred reaction 2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3-[(Z)-2-isocyanoethenyl]-1H-indole + 3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3-[(Z)-2-isocyanoethenyl]-3H-indole
-
?
3-[(E)-2-isocyanoethenyl]-1H-indole + geranyl diphosphate Fischerella ambigua UTEX 1903 preferred reaction 2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3-[(Z)-2-isocyanoethenyl]-1H-indole + 3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3-[(Z)-2-isocyanoethenyl]-3H-indole
-
?

Organism

Organism UniProt Comment Textmining
Fischerella ambigua
-
-
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Fischerella ambigua UTEX 1903
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-[(E)-2-isocyanoethenyl]-1H-indole + dimethylallyl diphosphate
-
Fischerella ambigua 3-[(E)-2-isocyanoethenyl]-2-(3-methylbut-2-en-1-yl)-1H-indole + 3-[(E)-2-isocyanoethenyl]-3-(3-methylbut-2-en-1-yl)-3H-indole
-
?
3-[(E)-2-isocyanoethenyl]-1H-indole + dimethylallyl diphosphate
-
Fischerella ambigua UTEX 1903 3-[(E)-2-isocyanoethenyl]-2-(3-methylbut-2-en-1-yl)-1H-indole + 3-[(E)-2-isocyanoethenyl]-3-(3-methylbut-2-en-1-yl)-3H-indole
-
?
3-[(E)-2-isocyanoethenyl]-1H-indole + geranyl diphosphate preferred reaction Fischerella ambigua 2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3-[(Z)-2-isocyanoethenyl]-1H-indole + 3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3-[(Z)-2-isocyanoethenyl]-3H-indole
-
?
3-[(E)-2-isocyanoethenyl]-1H-indole + geranyl diphosphate preferred reaction Fischerella ambigua UTEX 1903 2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3-[(Z)-2-isocyanoethenyl]-1H-indole + 3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3-[(Z)-2-isocyanoethenyl]-3H-indole
-
?

Synonyms

Synonyms Comment Organism
famD2
-
Fischerella ambigua