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Literature summary for 2.5.1.141 extracted from

  • Stevens, E.; Laabei, M.; Gardner, S.; Somerville, G.A.; Massey, R.C.
    Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase (2017), Sci. Rep., 7, 13744 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,6E)-farnesyl diphosphate + protoheme IX + H2O Staphylococcus aureus
-
 diphosphate + ferroheme o
-
 ?
(2E,6E)-farnesyl diphosphate + protoheme IX + H2O Staphylococcus aureus JE2
-
 diphosphate + ferroheme o
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus JE2
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + protoheme IX + H2O
-
 Staphylococcus aureus diphosphate + ferroheme o
-
 ?
(2E,6E)-farnesyl diphosphate + protoheme IX + H2O
-
 Staphylococcus aureus JE2 diphosphate + ferroheme o
-
 ?

Synonyms

Synonyms Comment Organism
cyoE
-
 Staphylococcus aureus
protoheme IX farnesyltransferase
-
 Staphylococcus aureus

General Information

General Information Comment Organism
malfunction without this enzyme, Staphylococcus aureus is repressed in its ability to secrete cytolytic toxins Staphylococcus aureus
metabolism the enzyme is essential for processing heme into the electron transport chain for use as an electron acceptor Staphylococcus aureus