Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
chloroplast | - |
Humulus lupulus | 9507 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | exclusive requirement for Mg2+ | Humulus lupulus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dimethylallyl diphosphate + naringenin chalcone | Humulus lupulus | - |
diphosphate + desmethylxanthohumol | - |
? | |
dimethylallyl diphosphate + phlorisobutyrophenone | Humulus lupulus | 61.9% of the activity with phlorisovalerophenone | diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one | - |
? | |
dimethylallyl diphosphate + phlorisovalerophenone | Humulus lupulus | best substrate | diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one | - |
? | |
dimethylallyl diphosphate + phlormethylbutanophenone | Humulus lupulus | 29.5% of the activity with phlorisovalerophenone | diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Humulus lupulus | E5RP65 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dimethylallyl diphosphate + naringenin chalcone | - |
Humulus lupulus | diphosphate + desmethylxanthohumol | - |
? | |
dimethylallyl diphosphate + phlorisobutyrophenone | 61.9% of the activity with phlorisovalerophenone | Humulus lupulus | diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one | - |
? | |
dimethylallyl diphosphate + phlorisovalerophenone | best substrate | Humulus lupulus | diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one | - |
? | |
dimethylallyl diphosphate + phlormethylbutanophenone | 29.5% of the activity with phlorisovalerophenone | Humulus lupulus | diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aromatic prenyltransferase | - |
Humulus lupulus |
PT-1 | - |
Humulus lupulus |
PT1 | - |
Humulus lupulus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
narrow | Humulus lupulus |
General Information | Comment | Organism |
---|---|---|
physiological function | PT-1 catalyzes the first transfer of dimethylallyl moiety to phloroglucinol derivatives, phlorisovalerophenone, phlorisobutyrophenone and phlormethylbutanophenone, leading to the formation of humulone and lupulone derivatives, i.e. Humulus lupulus bitter acids. PT-1 also recognizes naringenin chalcone as a flavonoid substrate to yield xanthohumol | Humulus lupulus |