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Literature summary for 2.5.1.122 extracted from

  • Zou, H.X.; Xie, X.; Zheng, X.D.; Li, S.M.
    The tyrosine O-prenyltransferase SirD catalyzes O-, N-, and C-prenylations (2011), Appl. Microbiol. Biotechnol., 89, 1443-1451.
    View publication on PubMed
Search for more literature for 2.5.1.122

Application

Application Comment Organism
synthesis the specific 4-O-prenylation of tyrosine derivatives by SirD could find usage for production of prenylated tyrosine derivatives by chemoenzymatic synthesis Leptosphaeria maculans

Cloned(Commentary)

Cloned (Comment) Organism
overproduction of His6-SirD in Escherichia coli Leptosphaeria maculans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dimethylallyl diphosphate + L-tyrosine Leptosphaeria maculans the enzyme is involved in biosynthesis of sirodesmin PL diphosphate + 4-O-dimethylallyl-L-tyrosine
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 ?

Organism

Organism UniProt Comment Textmining
Leptosphaeria maculans
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-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Leptosphaeria maculans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dimethylallyl diphosphate + 3-amino-L-tyrosine SirD catalyzes the regiospecific O-prenylation at position C4 of tyrosine and derivatives. 3-Amino-L-tyrosine is prenylated with 108% of the activity compared to L-tyrosine Leptosphaeria maculans diphosphate + 3-amino-4-O-dimethylallyl-L-tyrosine
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 ?
dimethylallyl diphosphate + 3-fluoro-DL-tyrosine SirD catalyzes the regiospecific O-prenylation at position C4 of tyrosine and derivatives. 3-Iodo-L-tyrosine is prenylated with 53.6% of the activity compared to L-tyrosine Leptosphaeria maculans diphosphate + 4-O-dimethylallyl-3-fluoro-DL-tyrosine
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 ?
dimethylallyl diphosphate + 3-iodo-L-tyrosine SirD catalyzes the regiospecific O-prenylation at position C4 of tyrosine and derivatives. 3-Iodo-L-tyrosine is prenylated with 27.3% of the activity compared to L-tyrosine Leptosphaeria maculans diphosphate + 4-O-dimethylallyl-3-iodo-L-tyrosine
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 ?
dimethylallyl diphosphate + L-tyrosine the enzyme is involved in biosynthesis of sirodesmin PL Leptosphaeria maculans diphosphate + 4-O-dimethylallyl-L-tyrosine
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 ?
dimethylallyl diphosphate + L-tyrosine SirD catalyzes the regiospecific O-prenylation at position C4 of tyrosine and derivatives Leptosphaeria maculans diphosphate + 4-O-dimethylallyl-L-tyrosine
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 ?
additional information SirD also catalyses the C-prenylation of L-Trp derivatives, in addition to the O-prenylation Leptosphaeria maculans ?
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 ?

Synonyms

Synonyms Comment Organism
SirD
-
 Leptosphaeria maculans

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Leptosphaeria maculans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Leptosphaeria maculans

General Information

General Information Comment Organism
physiological function the enzyme is involved in biosynthesis of sirodesmin PL Leptosphaeria maculans