Literature summary for 2.5.1.117 extracted from

Shino, M.; Hamada, T.; Shigematsu, Y.; Hirase, K.; Banba, S.
Action mechanism of bleaching herbicide cyclopyrimorate, a novel homogentisate solanesyltransferase inhibitor (2018), J. Pestic. Sci., 43, 233-239 .

Search for more literature for 2.5.1.117

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21-AI cells	Arabidopsis thaliana

Inhibitors

Inhibitors	Comment	Organism	Structure
3-(2-bromo-6-cyclopropylphenoxy)-6-chloropyridazin-4-ol	-	Arabidopsis thaliana
3-chloro-6-(2-cyclopropyl-6-methylphenoxy)pyridazine	-	Arabidopsis thaliana
5-chloro-2-(2,6-dimethylphenoxy)pyridin-3-ol	-	Arabidopsis thaliana
6-chloro-3-(2-cyclopropyl-3-methylphenoxy)pyridazin-4-ol	-	Arabidopsis thaliana
6-chloro-3-(2-cyclopropyl-4,6-dimethylphenoxy)pyridazin-4-ol	-	Arabidopsis thaliana
6-chloro-3-(2-cyclopropyl-5-methylphenoxy)pyridazin-4-ol	-	Arabidopsis thaliana
6-chloro-3-(2-cyclopropyl-6-ethylphenoxy)pyridazin-4-ol	-	Arabidopsis thaliana
6-chloro-3-(2-cyclopropyl-6-methoxyphenoxy)pyridazin-4-ol	-	Arabidopsis thaliana
6-chloro-3-(2-cyclopropylphenoxy)pyridazin-4-ol	-	Arabidopsis thaliana
6-chloro-3-(6-cyclopropyl-3-hydroxy-2-methylphenoxy)pyridazin-4-ol	-	Arabidopsis thaliana
cyclopyrimorate	weak inhibition	Arabidopsis thaliana
des-morpholinocarbonyl cyclopyrimorate	99% inhibition at 0.2 mM	Arabidopsis thaliana
haloxydine	-	Arabidopsis thaliana
additional information	not inhibited by mesotrione and norflurazon even at the concentration as high as 1 mM	Arabidopsis thaliana

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	20 mM used in assay conditions	Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
solanesyl diphosphate + homogentisate	Arabidopsis thaliana	-	diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	Q1ACB3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	-	Arabidopsis thaliana	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
farnesyl diphosphate + homogentisate	-	Arabidopsis thaliana	diphosphate + (3-(2E,6E)-farnesyl-2,5-dihydroxyphenyl)acetate	-	?
solanesyl diphosphate + homogentisate	-	Arabidopsis thaliana	diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2	-	?

Synonyms

Synonyms	Comment	Organism
HST	-	Arabidopsis thaliana

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00165	-	at pH 8.5 and 28°C	Arabidopsis thaliana	6-chloro-3-(2-cyclopropyl-4,6-dimethylphenoxy)pyridazin-4-ol
0.00239	-	at pH 8.5 and 28°C	Arabidopsis thaliana	6-chloro-3-(2-cyclopropyl-6-ethylphenoxy)pyridazin-4-ol
0.00265	-	at pH 8.5 and 28°C	Arabidopsis thaliana	6-chloro-3-(2-cyclopropyl-5-methylphenoxy)pyridazin-4-ol
0.00385	-	at pH 8.5 and 28°C	Arabidopsis thaliana	3-(2-bromo-6-cyclopropylphenoxy)-6-chloropyridazin-4-ol
0.00393	-	at pH 8.5 and 28°C	Arabidopsis thaliana	des-morpholinocarbonyl cyclopyrimorate
0.00919	-	at pH 8.5 and 28°C	Arabidopsis thaliana	haloxydine
0.0193	-	at pH 8.5 and 28°C	Arabidopsis thaliana	6-chloro-3-(2-cyclopropyl-3-methylphenoxy)pyridazin-4-ol
0.0213	-	at pH 8.5 and 28°C	Arabidopsis thaliana	6-chloro-3-(2-cyclopropylphenoxy)pyridazin-4-ol
0.0245	-	at pH 8.5 and 28°C	Arabidopsis thaliana	6-chloro-3-(2-cyclopropyl-6-methoxyphenoxy)pyridazin-4-ol
0.157	-	at pH 8.5 and 28°C	Arabidopsis thaliana	6-chloro-3-(6-cyclopropyl-3-hydroxy-2-methylphenoxy)pyridazin-4-ol
0.258	-	at pH 8.5 and 28°C	Arabidopsis thaliana	3-chloro-6-(2-cyclopropyl-6-methylphenoxy)pyridazine
0.463	-	at pH 8.5 and 28°C	Arabidopsis thaliana	5-chloro-2-(2,6-dimethylphenoxy)pyridin-3-ol
0.561	-	at pH 8.5 and 28°C	Arabidopsis thaliana	cyclopyrimorate

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Release 2023.1 (January 2023)