Literature summary for 2.5.1.114 extracted from

Rodriguez, V.; Vasudevan, S.; Noma, A.; Carlson, B.A.; Green, J.E.; Suzuki, T.; Chandrasekharappa, S.C.
Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA (2012), PLoS One, 7, e39297.

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Protein Variants

Protein Variants	Comment	Organism
D293A	mutant enzyme retains activity	Homo sapiens
E265A	mutation eliminates activity	Homo sapiens
K225A	mutation eliminates activity	Homo sapiens
T248A	mutant enzyme retains activity	Homo sapiens
Y242A	mutant enzyme retains activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q53H54	-	-

Synonyms

Synonyms	Comment	Organism
TYW2	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	the enzyme is overexpressed in breast cancer	up

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Release 2023.1 (January 2023)